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Molecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expression
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Orientador(es)
Resumo(s)
Flatfish metamorphosis is the most dramatic postnatal
developmental event in teleosts. Thyroid hormones
(TH), thyroxine (T4) and 3,3′-5′-triiodothyronine (T3) are
the necessary and sufficient factors that induce and regulate
flatfish metamorphosis. Most of the cellular and molecular
action of TH is directed through the binding of T3 to thyroid
nuclear receptors bound to promoters with consequent
changes in the expression of target genes. The conversion
of T4 to T3 and nuclear availability of T3 depends on the
expression and activity of a family of 3 selenocysteine
deiodinases that activate T4 into T3 or degrade T4 and T3.
Descrição
Palavras-chave
Thyroid hormones Metamorphosis Skin Muscle Flatfish Atlantic halibut Hippoglossus hippoglossus (Teleostei)
Contexto Educativo
Citação
M. A. Campinho & M. Galay-Burgos & N. Silva & R. A. Costa & R. N. Alves & G. E. Sweeney & D. M. Power, "Molecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expression" in Cell Tissue Res (2012) 350:333–346.
Editora
Springer Verlag