Publication
Decavanadate Toxicology and Pharmacological Activities: V-10 or V-1, Both or None?
| dc.contributor.author | Aureliano, M. | |
| dc.date.accessioned | 2017-04-07T15:57:35Z | |
| dc.date.available | 2017-04-07T15:57:35Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | This review covers recent advances in the understanding of decavanadate toxicology and pharmacological applications. Toxicological in vivo studies point out that V-10 induces several changes in several oxidative stress parameters, different from the ones observed for vanadate (V-1). In in vitro studies with mitochondria, a particularly potent V-10 effect, in comparison with V-1, was observed in the mitochondrial depolarization (IC50 = 40 nM) and oxygen consumption (99 nM). It is suggested that mitochondrial membrane depolarization is a key event in decavanadate induction of necrotic cardiomyocytes death. Furthermore, only decavanadate species and not V-1 potently inhibited myosin ATPase activity stimulated by actin (IC50 = 0.75 mu M) whereas exhibiting lower inhibition activities for Ca2+-ATPase activity (15 mu M) and actin polymerization (17 mu M). Because both calcium pump and actin decavanadate interactions lead to its stabilization, it is likely that V-10 interacts at specific locations with these proteins that protect against hydrolysis but, on the other hand, it may induce V-10 reduction to oxidovanadium(IV). Putting it all together, it is suggested that the pharmacological applications of V-10 species and compounds whose mechanism of action is still to be clarified might involve besides V-10 and V-1 also vanadium(IV) species. | |
| dc.identifier.doi | 10.1155/2016/6103457 | |
| dc.identifier.issn | 1942-0900 | |
| dc.identifier.other | AUT: MAA01296; | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/9756 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Hindawi Publishing Corporation | |
| dc.relation.isbasedon | WOS:000374468500001 | |
| dc.title | Decavanadate Toxicology and Pharmacological Activities: V-10 or V-1, Both or None? | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT | |
| oaire.citation.endPage | 6103457 | |
| oaire.citation.startPage | 6103457 | |
| oaire.citation.title | Oxidative Medicine and Cellular Longevity | |
| oaire.citation.volume | 2016 | |
| oaire.fundingStream | 5876 | |
| person.familyName | Aureliano | |
| person.givenName | Manuel | |
| person.identifier | 584146 | |
| person.identifier.ciencia-id | AA14-3490-DC5E | |
| person.identifier.orcid | 0000-0003-4858-3201 | |
| person.identifier.rid | I-3283-2012 | |
| person.identifier.scopus-author-id | 6603412860 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | |
| rcaap.type | article | |
| relation.isAuthorOfPublication | bb413661-7edd-4b57-8338-33889cfd05db | |
| relation.isAuthorOfPublication.latestForDiscovery | bb413661-7edd-4b57-8338-33889cfd05db | |
| relation.isProjectOfPublication | 868b4818-3efa-4edb-9202-c464d64fd38f | |
| relation.isProjectOfPublication.latestForDiscovery | 868b4818-3efa-4edb-9202-c464d64fd38f |
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