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Metabolomic profile and biological properties of sea lavender (Limonium algarvense Erben) plants cultivated with aquaculture wastewaters: implications for its use in herbal formulations and food additives

2021-12-14Journal article Open access
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dc.contributor.authorRodrigues, Maria João
dc.contributor.authorCastañeda-Loaiza, Viana
dc.contributor.authorMonteiro, Ivo
dc.contributor.authorPinela, José
dc.contributor.authorBarros, Lillian
dc.contributor.authorAbreu, Rui M. V.
dc.contributor.authorOliveira, Maria Conceição
dc.contributor.authorReis, Catarina
dc.contributor.authorSoares, Florbela
dc.contributor.authorPousão-Ferreira, Pedro
dc.contributor.authorPereira, Catarina
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2022-01-10T14:25:21Z
dc.date.available2022-01-10T14:25:21Z
dc.date.issued2021-12-14
dc.date.updated2021-12-23T15:06:40Z
dc.description.abstractWater extracts from sea lavender (<i>Limonium algarvense</i> Erben) plants cultivated in greenhouse conditions and irrigated with freshwater and saline aquaculture effluents were evaluated for metabolomics by liquid chromatography-tandem high-resolution mass spectrometry (LC-HRMS/MS), and functional properties by in vitro and ex vivo methods. In vitro antioxidant methods included radical scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric-reducing antioxidant power (FRAP), and copper and iron chelating assets. Flowers’ extracts had the highest compounds’ diversity (flavonoids and its derivatives) and strongest in vitro antioxidant activity. These extracts were further tested for ex vivo antioxidant properties by oxidative haemolysis inhibition (OxHLIA), lipid peroxidation inhibition by thiobarbituric acid reactive substances (TBARS) formation, and anti-melanogenic, anti-tyrosinase, anti-inflammation, and cytotoxicity. Extract from plants irrigated with 300 mM NaCl was the most active towards TBARS (IC<sub>50</sub> = 81 µg/mL) and tyrosinase (IC<sub>50</sub> = 873 µg/mL). In OxHLIA, the activity was similar for fresh- and saltwater-irrigated plants (300 mM NaCl; IC<sub>50</sub> = 136 and 140 µg/mL, respectively). Samples had no anti-inflammatory and anti-melanogenic abilities and were not toxic. Our results suggest that sea lavender cultivated under saline conditions could provide a flavonoid-rich water extract with antioxidant and anti-tyrosinase properties with potential use as a food preservative or as a functional ingredient in herbal supplements.pt_PT
dc.description.sponsorshipThe authors acknowledge the Faculty of Pharmacy and Centre for Neurosciences and Cell Biology (University of Coimbra, Portugal) that kindly offered the murine RAW 264.7 macrophages, and the Functional Biochemistry and Proteomics, and the Marine Molecular Bioengineering groups (Centre of Marine Sciences, Portugal) that provided the human embryonic kidney (HEK) 293, and the human hepatocellular carcinoma (HepG2) cell lines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFoods 10 (12): 3104 (2021)pt_PT
dc.identifier.doi10.3390/foods10123104pt_PT
dc.identifier.issn2304-8158
dc.identifier.urihttp://hdl.handle.net/10400.1/17455
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHalophytespt_PT
dc.subjectHerbal productspt_PT
dc.subjectIMTA systemspt_PT
dc.subjectSaline agriculturept_PT
dc.subjectSalinizationpt_PT
dc.subjectSalt tolerant plantspt_PT
dc.subjectSustainabilitypt_PT
dc.titleMetabolomic profile and biological properties of sea lavender (Limonium algarvense Erben) plants cultivated with aquaculture wastewaters: implications for its use in herbal formulations and food additivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.startPage3104pt_PT
oaire.citation.titleFoodspt_PT
oaire.citation.volume10pt_PT
person.familyNameRodrigues
person.familyNameCastañeda-Loaiza
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameMaria João
person.givenNameViana
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id2319-B2D8-AF48
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-8839-1389
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublicationa30bb840-c603-4acb-85a6-0fe2557651a5
relation.isAuthorOfPublication164572fc-85ed-4377-afd0-7ab4c8fdc79f
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery164572fc-85ed-4377-afd0-7ab4c8fdc79f

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