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Publication
O Impacto da grainha da uva na diabetes mellitus
| Name: | Description: | Size: | Format: | |
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| 1.97 MB | Adobe PDF |
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Abstract(s)
A diabetes mellitus (DM) é conhecida como uma das doenças crónicas mais debilitantes no mundo, sendo considerada bastante perigosa pois os indivíduos não sabem que possuem a doença até ao aparecimento e desenvolvimento de complicações. De acordo com os valores de referência, o diagnóstico da diabetes é feito quando glicemia de jejum ≥ 126 mg/dl; ou sintomas clássicos + glicemia ocasional ≥ 200mg/dl; ou glicemia ≥ 200 mg/dl às 2 horas, na prova de tolerância à glicose oral (PTGO) com 75 g de glicose; ou hemoglobina glicada A1c (HbA1c) ≥ 6,5%.
A uva, devido à sua composição química, tem vindo a ser alvo de atenção científica nos últimos anos devido às suas propriedades antioxidantes e anti- inflamatórias, podendo atuar na inibição de doenças como o cancro, diabetes e doenças inflamatórias e neurodegenerativas. As proantocianidinas são um tipo de flavonóides encontrados nesta fruta que parecem ter efeitos biológicos, incluindo antidiabético, pelo que são compostos que têm atraído a atenção não só da indústria alimentar, mas também de organizações de saúde devido aos seus potenciais benefícios para a saúde. A terapia com extrato de grainha da uva pode influenciar positivamente a homeostase da glucose e a secreção de insulina, juntamente com melhorias nos níveis de marcadores inflamatórios e do stress oxidativo.
A presente monografia tem como objetivo realizar uma revisão bibliográfica acerca do impacto da grainha da uva na DM, incluindo uma breve contextualização da doença e avaliando o nível de eficácia no benefício da mesma enquanto estratégia no combate desta patologia e na saúde.
Diabetes mellitus (DM) is known as one of the most debilitating chronic diseases in the world, and is considered quite dangerous because individuals do not know they have the disease until complications appear and develop. According to the reference values, diabetes is diagnosed when fasting blood glucose ≥ 126 mg/dl; or classic symptoms + occasional blood glucose ≥ 200mg/dl; or blood glucose ≥ 200 mg/dl at 2 hours, in the oral glucose tolerance test (OGTT) with 75 g of glucose; or glycated hemoglobin A1c (HbA1c) ≥ 6.5%. Due to its chemical composition, grapes have been the focus of scientific attention in recent years due to their antioxidant and anti-inflammatory properties, which may act to inhibit diseases such as cancer, diabetes and inflammatory and neurodegenerative diseases. Proanthocyanidins are a type of flavonoid found in this fruit that appear to have biological effects, including anti-diabetes, so they are compounds that have attracted the attention not only of the food industry, but also of health organizations due to their potential health benefits. Therapy with grape seed extract has significantly managed glucose homeostasis and insulin secretion, along with improvements in the levels of inflammatory markers and oxidative stress. The aim of this monograph is to carry out a literature review on the impact of grape seed on DM, including a brief contextualization of the disease and evaluating its level of effectiveness as a strategy to combat this pathology and improve health.
Diabetes mellitus (DM) is known as one of the most debilitating chronic diseases in the world, and is considered quite dangerous because individuals do not know they have the disease until complications appear and develop. According to the reference values, diabetes is diagnosed when fasting blood glucose ≥ 126 mg/dl; or classic symptoms + occasional blood glucose ≥ 200mg/dl; or blood glucose ≥ 200 mg/dl at 2 hours, in the oral glucose tolerance test (OGTT) with 75 g of glucose; or glycated hemoglobin A1c (HbA1c) ≥ 6.5%. Due to its chemical composition, grapes have been the focus of scientific attention in recent years due to their antioxidant and anti-inflammatory properties, which may act to inhibit diseases such as cancer, diabetes and inflammatory and neurodegenerative diseases. Proanthocyanidins are a type of flavonoid found in this fruit that appear to have biological effects, including anti-diabetes, so they are compounds that have attracted the attention not only of the food industry, but also of health organizations due to their potential health benefits. Therapy with grape seed extract has significantly managed glucose homeostasis and insulin secretion, along with improvements in the levels of inflammatory markers and oxidative stress. The aim of this monograph is to carry out a literature review on the impact of grape seed on DM, including a brief contextualization of the disease and evaluating its level of effectiveness as a strategy to combat this pathology and improve health.
Description
Keywords
Diabetes mellitus glicose grainha de uva antioxidante proantocianidina