Novel bioactive parathyroid hormone and related peptides in teleost fish

Canario, Adelino V. M.; Rotllant, J.; Fuentes, J.; Guerreiro, P. M.; Teodósio, H. R.; Power, Deborah; Clark, M. S.

http://hdl.handle.net/10400.1/3850

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Authors

Canario, Adelino V. M.

Abstract(s)

We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.

Keywords

Parathyroid hormone Parathyroid hormone-related peptide Calciotropic Receptor Adenylate cyclase Phospholipase C

URI

http://hdl.handle.net/10400.1/3850

Citation

Canario, A. V. M.; Rotllant, J.; Fuentes, J.; Guerreiro, P. M.; Teodosio, H. R.; Power, D. M.; Clark, M. S.Novel bioactive parathyroid hormone and related peptides in teleost fish, Febs Letters, 580, 1, 291-299, 2006.