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Dominant effects of the antiepileptic drug carbamazepine over climate change stressors on mytilus galloprovincialis toxicity

2026-04Artigo científico Acesso restrito
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datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorNascimento Bajwa, Farhat-Un-Nisá
dc.contributor.authorCunha, Marta
dc.contributor.authorVilke, Juliano Marcelo
dc.contributor.authorDias Duarte Fragoso, Bruno
dc.contributor.authorBorges, Rodrigo
dc.contributor.authorSoares, Amadeu M. V. M.
dc.contributor.authorFreitas, Rosa
dc.contributor.authorGARCIA DA FONSECA, TAINÁ
dc.date.accessioned2026-03-04T12:52:02Z
dc.date.available2026-03-04T12:52:02Z
dc.date.issued2026-04
dc.description.abstractPharmaceuticals have become ubiquitous in marine realms, raising concerns about their ecological effects. This study investigates the ecotoxicological impact of the antiepileptic drug carbamazepine on marine mussels (Mytilus galloprovincialis) under increased seawater temperature and salinity, reflecting projected climate change scenarios. Mussels were exposed to carbamazepine (CBZ, 5 μg L− 1 ) for 28 days in both current (17 ◦C and salinity 35) and predicted (23 ◦C and salinity 40) conditions. A multiple-biomarker approach was employed to assess alterations in energy balance, antioxidant and biotransformation systems, membrane damage, neurotoxicity, and genotoxicity in gills and digestive glands. The results indicated that CBZ caused significant oxidative stress, disruption in energy metabolism, and neurotoxic and genotoxic effects, regardless of the combination of stressors. Moreover, biomarkers were modulated by the time of exposure, suggesting a time-specific response in mussels exposed to either a single or multiple stressors. The findings underscore the complex interplay between pharmaceutical pollution and climate change stressors. This study provides crucial insights into the toxicity of pharmaceuticals in marine environments under future climate change scenarios. To our knowledge, this is the first study to investigate the effects of CBZ on marine mussels in conjunction with the simultaneous rise in seawater temperature and salinity.eng
dc.description.sponsorshipUID/50017/2025
dc.identifier.doi10.1016/j.marpolbul.2025.119205
dc.identifier.issn0025-326X
dc.identifier.urihttp://hdl.handle.net/10400.1/28325
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Marine and Environmental Research (CIMA)
dc.relationAquatic Research Infrastructure Network
dc.relation.ispartofMarine Pollution Bulletin
dc.rights.uriN/A
dc.subjectMultiple stressors
dc.subjectPharmaceutical pollution
dc.subjectBiomarkers
dc.subjectGenotoxicity
dc.subjectMarine mussels
dc.titleDominant effects of the antiepileptic drug carbamazepine over climate change stressors on mytilus galloprovincialis toxicityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberLA/P/0094/2020
oaire.awardNumberUIDP/00350/2020
oaire.awardNumberLA/P/0069/2020
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Marine and Environmental Research (CIMA)
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00350%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
oaire.citation.startPage119205
oaire.citation.titleMarine Pollution Bulletin
oaire.citation.volume225
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNascimento Bajwa
person.familyNameVilke
person.familyNameDias Duarte Fragoso
person.familyNameBorges
person.familyNameGARCIA DA FONSECA
person.givenNameFarhat-Un-Nisá
person.givenNameJuliano Marcelo
person.givenNameBruno
person.givenNameRodrigo
person.givenNameTAINÁ
person.identifier.ciencia-id6017-EA2C-5FD8
person.identifier.ciencia-id2C1A-11F1-3BF2
person.identifier.ciencia-id6316-2939-C074
person.identifier.ciencia-idCC10-4E47-B6DD
person.identifier.orcid0000-0003-2957-0245
person.identifier.orcid0000-0002-1881-6978
person.identifier.orcid0000-0003-4531-3265
person.identifier.orcid0000-0003-4245-1881
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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