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Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles

2018Journal article Open access
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dc.contributor.authorBraz, Luis
dc.contributor.authorGrenha, Ana
dc.contributor.authorCorvo, Marta C.
dc.contributor.authorLourenço, João P.
dc.contributor.authorFerreira, Domingos
dc.contributor.authorSarmento, Bruno
dc.contributor.authorCosta, Ana M. Rosa da
dc.date.accessioned2018-02-19T12:02:41Z
dc.date.available2019-02-01T01:30:22Z
dc.date.issued2018
dc.description.abstractThe development of LBG-based nanoparticles intending an application in oral immunization is presented. Nanoparticle production occurred by mild polyelectrolyte complexation, requiring the chemical modification of LBG. Three LBG derivatives were synthesized, namely a positively charged ammonium derivative (LBGA) and negatively charged sulfate (LBGS) and carboxylate (LBGC) derivatives. These were characterized by Fourier-transform infrared spectroscopy, elemental analysis, nuclear magnetic resonance spectroscopy, gel permeation chromatography, and x-ray diffraction. As a pharmaceutical application was aimed, a toxicological analysis of the derivatives was performed by both MTT test and LDH release assay. Several nanoparticle formulations were produced using LBGA or chitosan (CS) as positively charged polymers, and LBGC or LBGS as negatively charged counterparts, producing nanoparticles with adequate properties regarding an application in oral immunization.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.carbpol.2017.11.052pt_PT
dc.identifier.issn0144-8617
dc.identifier.otherAUT: LVB02213; AMG02212; JLO01215; AMC01695;
dc.identifier.urihttp://hdl.handle.net/10400.1/10376
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCarboxylated locust bean gumpt_PT
dc.subjectPolyelectrolyte complexationpt_PT
dc.subjectPolymeric nanoparticlespt_PT
dc.subjectSulfated locust bean gumpt_PT
dc.subjectTetraalkylammonium locust bean gumpt_PT
dc.titleSynthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-FCF%2F100291%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FQUI%2FUI4023%2F2014/PT
oaire.citation.endPage985pt_PT
oaire.citation.startPage974pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume181pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream5876
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person.familyNameBraz
person.familyNameGrenha
person.familyNameLourenço
person.familyNameRosa da Costa
person.givenNameLuis
person.givenNameAna
person.givenNameJoão P.
person.givenNameAna M
person.identifier634248
person.identifier305029
person.identifier.ciencia-idBA15-0A43-361F
person.identifier.ciencia-id091C-0D58-7225
person.identifier.ciencia-idF81F-A1F0-2A7C
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.orcid0000-0002-1500-1976
person.identifier.orcid0000-0002-2136-1396
person.identifier.orcid0000-0002-0501-6672
person.identifier.orcid0000-0003-0225-9537
person.identifier.ridE-1901-2012
person.identifier.ridH-1392-2017
person.identifier.ridA-7758-2008
person.identifier.ridE-2165-2012
person.identifier.scopus-author-id55996112700
person.identifier.scopus-author-id8607930100
person.identifier.scopus-author-id57195730600
person.identifier.scopus-author-id53986075100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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