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New insights into the phytochemical profile and biological properties of Lycium intricatum Bois. (Solanaceae)

2023-02-22Journal article Open access
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dc.contributor.authorBendjedou, Houaria
dc.contributor.authorBenamar, Houari
dc.contributor.authorBennaceur, Malika
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorPereira, Catarina Guerreiro
dc.contributor.authorTrentin, Riccardo
dc.contributor.authorL, Custódio
dc.date.accessioned2023-03-11T13:03:16Z
dc.date.available2023-03-11T13:03:16Z
dc.date.issued2023-02-22
dc.date.updated2023-03-10T14:02:14Z
dc.description.abstractThis work aimed to boost the valorisation of Lycium intricatum Boiss. L. as a source of high added value bioproducts. For that purpose, leaves and root ethanol extracts and fractions (chloroform, ethyl acetate, n-butanol, and water) were prepared and evaluated for radical scavenging activity (RSA) on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,20 -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, ferric reducing antioxidant power (FRAP), and metal chelating potential against copper and iron ions. Extracts were also appraised for in vitro inhibition of enzymes implicated on the onset of neurological diseases (acetylcholinesterase: AChE and butyrylcholinesterase: BuChE), type-2 diabetes mellitus (T2DM, α-glucosidase), obesity/acne (lipase), and skin hyperpigmentation/food oxidation (tyrosinase). The total content of phenolics (TPC), flavonoids (TFC), and hydrolysable tannins (THTC) was evaluated by colorimetric methods, while the phenolic profile was determined by high-performance liquid chromatography, coupled to a diode-array ultraviolet detector (HPLCUV-DAD). Extracts had significant RSA and FRAP, and moderate copper chelation, but no iron chelating capacity. Samples had a higher activity towards α-glucosidase and tyrosinase, especially those from roots, a low capacity to inhibit AChE, and no activity towards BuChE and lipase. The ethyl acetate fraction of roots had the highest TPC and THTC, whereas the ethyl acetate fraction of leaves had the highest flavonoid levels. Gallic, gentisic, ferulic, and trans-cinnamic acids were identified in both organs. The results suggest that L. intricatum is a promising source of bioactive compounds with food, pharmaceutical, and biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPlants 12 (5): 996 (2023)pt_PT
dc.identifier.doi10.3390/plants12050996pt_PT
dc.identifier.eissn2223-7747
dc.identifier.urihttp://hdl.handle.net/10400.1/19225
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationNot Available
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMedicinal plantspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectDiabetespt_PT
dc.subjectTyrosinasept_PT
dc.subjectGojipt_PT
dc.titleNew insights into the phytochemical profile and biological properties of Lycium intricatum Bois. (Solanaceae)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleNot Available
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00425%2F2017%2FCP1391%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.issue5pt_PT
oaire.citation.startPage996pt_PT
oaire.citation.titlePlantspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRodrigues
person.familyNameGuerreiro Pereira
person.familyNameTrentin
person.familyNameCustódio
person.givenNameMaria João
person.givenNameCatarina Alexandra
person.givenNameRiccardo
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0002-2886-3364
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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