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Coupling sea lavender (Limonium algarvense Erben) and green tea (Camellia sinensis (L.) Kuntze) to produce an innovative herbal beverage with enhanced enzymatic inhibitory properties

2019-01Journal article Restricted
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dc.contributor.authorRodrigues, Maria João
dc.contributor.authorOliveira, M.
dc.contributor.authorNeves, V.
dc.contributor.authorOvelheiro, Andreia
dc.contributor.authorPereira, C. A.
dc.contributor.authorNeng, N. R.
dc.contributor.authorNogueira, J. M. F.
dc.contributor.authorVarela, J.
dc.contributor.authorBarreira, Luísa
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2020-07-24T10:53:25Z
dc.date.available2020-07-24T10:53:25Z
dc.date.issued2019-01
dc.description.abstractHerbal beverages containing mixtures of L. algarvense (LA) flowers and C. sinensis (CS) were prepared and their inhibitory properties towards enzymes related with Alzheimer's (acetyl-and butyrylcholinesterase) and Type-2 diabetes mellitus (alpha-amylase and alpha-glucosidase) were evaluated for the first time. Samples were also appraised for antioxidant capacity and phenolic contents by high-performance liquid chromatography with diode-array detection (HPLC-DAD). Both synergistic and antagonistic interactions were observed: LA samples (infusion: IC50 = 0.22 mg/mL; decoction: 0.39 mg/mL) had higher acetylcholinesterase inhibition than CS and mixtures resulted in stronger enzymatic inhibition. CS had the highest rat alpha-glucosidase inhibition (infusion: IC50 = 3.91 mg/mL; decoction: IC50 = 2.50 mg/mL), which decreased when combined with LA. LA and CS samples had strong antioxidant activity, whereas LA and CS mixtures exhibited higher OH center dot radical-scavenging (0.56 <= SE <= 1.07) and anti-lipid peroxidation capacity (0.39 <= SE <= 0.81). CS had higher phenolic contents (infusion: 209 mg/g DW; decoction: 169 mg/g DW) and its combination with LA increased the phenolic diversity of the mixtures. Our results indicate that LA and CS infusions and decoctions and their combinations have relevant in vitro neuroprotective, antidiabetic and antioxidant properties and could be further explored as potential innovative functional beverages able to reduce the progression of neurodegenerative diseases and diabetic complications, and to prevent oxidative stress and lipid oxidation related diseases. (c) 2017 SAAB. Published by Elsevier B.V. All rights reserved.
dc.description.sponsorshipFCT - Foundation for Science and TechnologyPortuguese Foundation for Science and Technology
dc.description.sponsorshipPortuguese National Budget funding through the XtremeBio project [PTDC/MAR-EST/4346/2012]
dc.description.sponsorshipPortuguese National Budget funding [CCMAR/Multi/04326/2013]
dc.description.sponsorshipFCT Investigator Programme [IF/00049/2012]
dc.description.sponsorshipFCTPortuguese Foundation for Science and Technology [SFRH/BD/116604/2016, SFRH/BD/94407/2013, SFRH/BD/123658/2016, SFRH/BPD/86071/2012, UID/Multi/00612/2013]
dc.identifier.doi10.1016/j.sajb.2017.12.003
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.urihttp://hdl.handle.net/10400.1/14490
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier Science Bv
dc.relationHalophytes: a precious resource of nutritional elements and bioactive compounds
dc.relationDESENVOLVIMENTO E APLICAÇÃO DE METODOLOGIAS ANALÍTICAS INOVADORAS COMO TÉCNICAS NÃO INVASIVAS PARA RASTREIO CLÍNICO E TOXICOLOGIA FORENSE
dc.subjectKey enzymes relevant
dc.subjectIn-vitro
dc.subjectAntioxidant activity
dc.subjectAlzheimers-disease
dc.subjectDiabetes-mellitus
dc.subjectAlpha-glucosidase
dc.subjectMedicinal-plants
dc.subjectConsumption
dc.subjectInfusions
dc.subjectPhenolics
dc.titleCoupling sea lavender (Limonium algarvense Erben) and green tea (Camellia sinensis (L.) Kuntze) to produce an innovative herbal beverage with enhanced enzymatic inhibitory properties
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHalophytes: a precious resource of nutritional elements and bioactive compounds
oaire.awardTitleDESENVOLVIMENTO E APLICAÇÃO DE METODOLOGIAS ANALÍTICAS INOVADORAS COMO TÉCNICAS NÃO INVASIVAS PARA RASTREIO CLÍNICO E TOXICOLOGIA FORENSE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR-EST%2F4346%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F94407%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F86071%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00612%2F2013/PT
oaire.citation.endPage94
oaire.citation.startPage87
oaire.citation.titleSouth African Journal of Botany
oaire.citation.volume120
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStreamSFRH
oaire.fundingStream5876
person.familyNameRodrigues
person.familyNameOvelheiro
person.familyNameBarreira
person.familyNameCustódio
person.givenNameMaria João
person.givenNameAndreia
person.givenNameLuísa
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id9516-FB49-B62C
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-4528-6300
person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
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