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Chemical characterization of volatile and non-volatile constituents of aqueous extracts from euphorbia officinarum and E. resinifera: influence of extraction conditions on antioxidant and α-glucosidase inhibitory activities

2026-08Artigo científico Acesso restrito
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorBOUTOUB, OUMAIMA
dc.contributor.authorEl Ghadraoui, Lahsen
dc.contributor.authorEl-Guendouz, Soukaina
dc.contributor.authorAazza, Smail
dc.contributor.authorFigueiredo, Ana Cristina
dc.contributor.authorSilva, José Paulo da
dc.contributor.authorMiguel, Maria da Graça
dc.date.accessioned2026-09-19T09:35:00Z
dc.date.available2026-09-19T09:35:00Z
dc.date.issued2026-08
dc.description.abstractThis study performed a chemical characterization of Euphorbia officinarum and Euphorbia resinifera volatile and non-volatile aqueous extracts. It was also evaluated how extraction variables (extraction time and plant-tosolvent ratio, PSR) influenced the chemical composition and biological responses of the aqueous extracts of four populations of E. officinarum and one population of E. resinifera. The experimental results were fitted using second-order polynomial equations for all response variables. The volatiles (essential oils) were isolated by hydrodistillation and analyzed for quantification and component identification, by gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS), respectively. The volatile fraction of E. officinarum contained higher percentages of oxygenated monoterpenes and phenylpropanoids, whereas palmitic acid predominated in E. resinifera. Liquid chromatography-mass spectrometry (LC-MS) was used to analyze the aqueous extract of both species and the tentatively annotated compounds included particularly flavonoids, coumarins, oxylipins, and aliphatic dicarboxylic acids. Two-way ANOVA and response surface methodology highlighted that PSR was generally the main factor affecting the measured responses, whereas the influence of extraction time was response- and population-dependent. In addition, Pearson correlation and principal component analyses showed that the in vitro biological activities were more dependent on phytochemical composition than on total phenolic content.eng
dc.description.sponsorshipUID/04326/2025; UID/PRR/04326/2025
dc.identifier.doi10.1016/j.jarmap.2026.100741
dc.identifier.issn2214-7861
dc.identifier.urihttp://hdl.handle.net/10400.1/29478
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre for Ecology, Evolution and Environmental Changes
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofJournal of Applied Research on Medicinal and Aromatic Plants
dc.rights.uriN/A
dc.subjectEuphorbia officinarum
dc.subjectEuphorbia resinifera
dc.subjectAqueous extracts
dc.subjectResponse surface methodology
dc.subjectPhytochemical profiling
dc.subjectAntioxidant activity
dc.subjectα-glucosidase inhibition
dc.titleChemical characterization of volatile and non-volatile constituents of aqueous extracts from euphorbia officinarum and E. resinifera: influence of extraction conditions on antioxidant and α-glucosidase inhibitory activitieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/BIA/00329/2019
oaire.awardNumberLA/P/0101/2020
oaire.awardTitleCentre for Ecology, Evolution and Environmental Changes
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIA%2F00329%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.startPage100741
oaire.citation.titleJournal of Applied Research on Medicinal and Aromatic Plants
oaire.citation.volume54
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBOUTOUB
person.familyNameEl-Guendouz
person.familyNameSilva
person.familyNameMiguel
person.givenNameOUMAIMA
person.givenNameSoukaina
person.givenNameJosé Paulo da
person.givenNameMaria da Graça
person.identifierhttps://scholar.google.com/citations?user=CYBI8q8AAAAJ&hl=fr
person.identifier.ciencia-idAD1D-38AE-BA47
person.identifier.ciencia-id3E11-53A1-4D90
person.identifier.ciencia-id3413-C4F4-73F7
person.identifier.ciencia-id6110-6FE7-DF28
person.identifier.orcid0000-0002-3341-9452
person.identifier.orcid0000-0002-6458-7328
person.identifier.orcid0000-0003-2507-4228
person.identifier.ridA-4606-2008
person.identifier.scopus-author-id57190122389
person.identifier.scopus-author-id7201733236
person.identifier.scopus-author-id35562054500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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