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Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?

2023-06-27Journal article Open access
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dc.contributor.authorCorreia, Cátia
dc.contributor.authorFerreira, Anita
dc.contributor.authorFernandes, Mónica T.
dc.contributor.authorSilva, Bárbara M.
dc.contributor.authorEsteves, Filipa
dc.contributor.authorLeitao, Helena
dc.contributor.authorBragança, José
dc.contributor.authorCalado, Sofia
dc.date.accessioned2023-07-27T14:44:06Z
dc.date.available2023-07-27T14:44:06Z
dc.date.issued2023-06-27
dc.date.updated2023-07-13T14:06:57Z
dc.description.abstractCardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO) as the leading cause of death, contributing to a significant and growing global health and economic burden. Despite advancements in clinical approaches, there is a critical need for innovative cardiovascular treatments to improve patient outcomes. Therapies based on adult stem cells (ASCs) and embryonic stem cells (ESCs) have emerged as promising strategies to regenerate damaged cardiac tissue and restore cardiac function. Moreover, the generation of human induced pluripotent stem cells (iPSCs) from somatic cells has opened new avenues for disease modeling, drug discovery, and regenerative medicine applications, with fewer ethical concerns than those associated with ESCs. Herein, we provide a state-of-the-art review on the application of human pluripotent stem cells in CVD research and clinics. We describe the types and sources of stem cells that have been tested in preclinical and clinical trials for the treatment of CVDs as well as the applications of pluripotent stem-cell-derived in vitro systems to mimic disease phenotypes. How human stem-cell-based in vitro systems can overcome the limitations of current toxicological studies is also discussed. Finally, the current state of clinical trials involving stem-cell-based approaches to treat CVDs are presented, and the strengths and weaknesses are critically discussed to assess whether researchers and clinicians are getting closer to success.pt_PT
dc.description.sponsorshipB.M.S. was awarded with a Ph.D. fellowship (reference: 2022.13253.BDANA) by Fundação para a Ciência e Tecnologia (FCT). S.M.C is supported by a Stimulus of Scientific Employment, Individual Support (2020.01532.CEECIND) by FCT. J.B. is grateful to the FCT and the Comissão de Coordenação e Desenvolvimento Regional do Algarve (CCDR Algarve) for the project ALG-45-2020-41 and to Algarve Biomedical Center (ABC) for the award “Bolsa de Investigação Translacional—José Mariano Gago by ABC, 2022”. M.T.F. thanks the FCT for funding the project with the reference 2022.09209.PTDC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifierdoi: 10.3390/cells12131727
dc.identifier.citationCells 12 (13): 1727 (2023)pt_PT
dc.identifier.doi10.3390/cells12131727pt_PT
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/10400.1/19880
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationIdentification and functional analysis of genetic variants in left ventricular noncompaction cardiomyopathy
dc.relationExploring CITED2 role in glioblastoma stem cell biology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHuman stem cellspt_PT
dc.subjectCardiovascular diseasespt_PT
dc.subjectiPSCpt_PT
dc.subjectDisease modelingpt_PT
dc.subjectCell therapypt_PT
dc.titleHuman stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIdentification and functional analysis of genetic variants in left ventricular noncompaction cardiomyopathy
oaire.awardTitleExploring CITED2 role in glioblastoma stem cell biology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.01532.CEECIND%2FCP1613%2FCT0005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.09209.PTDC/PT
oaire.citation.issue13pt_PT
oaire.citation.startPage1727pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamCEEC IND 3ed
oaire.fundingStream3599-PPCDT
person.familyNameCorreia
person.familyNameFerreira
person.familyNameTeotónio Fernandes
person.familyNameOleiro Esteves
person.familyNameLeitao
person.familyNameBragança
person.familyNameCalado
person.givenNameCátia
person.givenNameAnita
person.givenNameMónica Alexandra
person.givenNameFilipa Alexandra
person.givenNameHelena
person.givenNameJosé
person.givenNameSofia
person.identifier.ciencia-id3017-A30B-6C8E
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person.identifier.ciencia-idAC1D-FA9D-F66F
person.identifier.ciencia-id7C1A-91BA-B6A0
person.identifier.orcid0000-0002-2228-5292
person.identifier.orcid0009-0002-2285-988X
person.identifier.orcid0000-0002-1206-1367
person.identifier.orcid0000-0001-6596-2671
person.identifier.orcid0000-0001-9566-400X
person.identifier.orcid0000-0001-5509-4145
person.identifier.ridK-2202-2016
person.identifier.scopus-author-id6602220001
person.identifier.scopus-author-id56426215600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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