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Plant-based potential in diabetes management: in vitro antioxidant, wound-healing, and enzyme inhibitory activities of southern algarve species

2025-06-01Journal article Open access
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dc.contributor.authorSaraiva de Carvalho, Isabel Maria Marques
dc.contributor.authorMestre Viegas, Cláudia Sofia
dc.contributor.authorMarkiewicz, Marta
dc.contributor.authorGalanty, Agnieszka
dc.contributor.authorPaśko, Paweł
dc.contributor.authorJakupović, Lejsa
dc.contributor.authorKončić, Marijana Zovko
dc.date.accessioned2025-07-25T09:04:52Z
dc.date.available2025-07-25T09:04:52Z
dc.date.issued2025-06-01
dc.description.abstractType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by impaired glucose regulation. This study evaluated the antioxidant and antidiabetic potential of aqueous extracts from four plant species from the southern Algarve: Aristolochia baetica, Chelidonium majus, Dittrichia viscosa, and Lavandula viridis, using non-cellular in vitro assays. HPLC/PDA was used to identify active compounds. Antioxidant activity was assessed by using TAA, FRAP, RP, and DPPH assays; antidiabetic potential through alpha-glucosidase and alpha-amylase inhibition; and wound healing relevance through elastase, collagenase, and lipoxygenase inhibition. D. viscosa showed the highest antioxidant activity (FRAP: 1132.99 +/- 19.54 mg TE/g dw; DPPH IC50 = 25.85 +/- 0.75 mu g/mL) and total phenolic/flavonoid content, with a diverse profile including caffeic and chlorogenic acids, isoquercetin, and quercetin. It also exhibited potent alpha-glucosidase inhibition (IC50 = 0.61 +/- 0.06 mg/mL), outperforming acarbose. L. viridis had the highest total phenolic content (39.04 mg/g), while A. baetica demonstrated the strongest anti-elastase, anti-collagenase, and lipoxygenase activity, suggesting wound-healing potential. C. majus showed the weakest effects. A strong correlation was observed between phenolic content and antioxidant/antidiabetic activity. These findings support further in vivo studies on D. viscosa and A. baetica for potential use in T2DM management and diabetic wound healing.eng
dc.identifier.doi10.3390/molecules30112432
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.1/27492
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMediterranean Institute for Agriculture, Environment and Development
dc.relation.ispartofMolecules
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDiabetes mellitus
dc.subjectAntioxidants
dc.subjectWound-healing
dc.subjectAntidiabetic potential
dc.subjectMedicinal plant
dc.titlePlant-based potential in diabetes management: in vitro antioxidant, wound-healing, and enzyme inhibitory activities of southern algarve specieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMediterranean Institute for Agriculture, Environment and Development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05183%2F2020/PT
oaire.citation.issue11
oaire.citation.startPage2432
oaire.citation.titleMolecules
oaire.citation.volume30
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSaraiva de Carvalho
person.familyNameMestre Viegas
person.givenNameIsabel Maria Marques
person.givenNameCláudia Sofia
person.identifier.ciencia-id591A-3777-B036
person.identifier.ciencia-idBC13-CBFD-ECA6
person.identifier.orcid0000-0001-8057-3404
person.identifier.orcid0000-0001-6668-2778
person.identifier.scopus-author-id35995183800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationaf26e659-578b-4e5f-a649-384cd5e4f8e3
relation.isAuthorOfPublication0bc1b0e2-46bd-4fb1-a3aa-f27ca4a55695
relation.isAuthorOfPublication.latestForDiscoveryaf26e659-578b-4e5f-a649-384cd5e4f8e3
relation.isProjectOfPublication823bd652-ee6c-4479-91c5-06095bc37e9c
relation.isProjectOfPublication.latestForDiscovery823bd652-ee6c-4479-91c5-06095bc37e9c

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