Comparative study of family 2 GPCRs in Fugu rubripes

Cardoso, João CR; Power, Deborah; Park, Melody

http://hdl.handle.net/10400.1/5392

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Comparative study of family 2 GPCRs in Fugu rubripes.pdf		136.48 KB	Adobe PDF	Download

Send Feedback

Authors

Cardoso, João CR

Power, Deborah

Park, Melody

Abstract(s)

In this study, members of family 2 GPCRs, one of the largest families of receptors in vertebrates, were isolated and characterized in the genome of the Japanese pufferfish, Fugu rubripes, and compared with the orthologous genes in other vertebrates. Phylogenetic analysis carried out with all vertebrate family 2 GPCR members indicated that CALR/CGRPR and CRF are the most divergent receptor group within this family and that the remaining members appear to originate from a common ancestral gene precursor.