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Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research

dc.contributor.authorEsteves, Filipa
dc.contributor.authorVilhena Catarino Brito, David
dc.contributor.authorRajado, Ana Teresa
dc.contributor.authorSilva, NĂĄdia
dc.contributor.authorApolĂłnio, Joana
dc.contributor.authorRoberto, VĂąnia
dc.contributor.authorAndrade, Raquel
dc.contributor.authorCalado, Sofia
dc.contributor.authorFaleiro, Maria Leonor
dc.contributor.authorAlbuquerque Andrade de Matos, Carlos Adriano
dc.contributor.authorMarques, Nuno
dc.contributor.authorMarreiros, Ana
dc.contributor.authorNzwalo, HipĂłlito
dc.contributor.authorPais, Sandra
dc.contributor.authorPalmeirim, Isabel
dc.contributor.authorSimĂŁoa, SĂłnia
dc.contributor.authorJoaquim, Natércia
dc.contributor.authorMiranda, Rui
dc.contributor.authorPĂȘgas, AntĂłnio
dc.contributor.authorRaposo, Daniela Marques
dc.contributor.authorSardo, Ana
dc.contributor.authorAraĂșjo, InĂȘs
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorCastelo-Branco, Pedro
dc.contributor.authorBragança, José
dc.date.accessioned2024-12-16T11:53:46Z
dc.date.available2024-12-16T11:53:46Z
dc.date.issued2024-12
dc.description.abstractHuman induced pluripotent stem cells (hiPSCs) hold promises to model and understand human diseases, including those associated with ageing. Here, we describe ABCRIi001-A, a hiPSC line generated from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female enrolled in a study for development of an ageing score (ALFA Score). PBMCs were reprogrammed using three Sendai virus-based reprogramming vectors (hKOS, hc-Myc, and hKlf4). ABCRIi001-A showed normal morphology and karyotype, viral clearance, absence of genomic aberrations, and their pluripotency was confirmed by expression of pluripotency-related markers and their ability to differentiate into the three germ layers. ABCRIi001-A is valuable for ageing-related studies.eng
dc.description.sponsorshipALG-01-0145-FEDER-072586
dc.identifier.doi10.1016/j.scr.2024.103576
dc.identifier.issn1873-5061
dc.identifier.urihttp://hdl.handle.net/10400.1/26482
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.ispartofStem Cell Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleEstablishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing researcheng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage103576
oaire.citation.titleStem Cell Research
oaire.citation.volume81
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameEsteves
person.familyNameVilhena Catarino Brito
person.familyNameRajado
person.familyNameSilva
person.familyNameApolĂłnio
person.familyNameRoberto
person.familyNameAndrade
person.familyNameCalado
person.familyNameFaleiro
person.familyNameAlbuquerque Andrade de Matos
person.familyNameMarques
person.familyNameMarreiros
person.familyNameNzwalo
person.familyNamePais
person.familyNamePalmeirim
person.familyNameJoaquim
person.familyNameNĂłbrega
person.familyNameCastelo-Branco
person.familyNameBragança
person.givenNameFilipa
person.givenNameDavid
person.givenNameAna Teresa
person.givenNameNĂĄdia
person.givenNameJoana
person.givenNameVĂąnia
person.givenNameRaquel
person.givenNameSofia
person.givenNameMaria Leonor
person.givenNameCarlos Adriano
person.givenNameNuno
person.givenNameAna
person.givenNameHipĂłlito
person.givenNameSandra
person.givenNameIsabel
person.givenNameNatércia
person.givenNameClévio
person.givenNamePedro
person.givenNameJosé
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