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Abstract(s)
The first attempts to induce mutations in biological
systems using chemical compounds go back to the
beginning of the past century. However, it was during
World War II that the two most relevant names in
chemical mutagenesis, Charlotte Auerbach and Iosif
A. Rapoport, established the mutagenic properties of
several chemical compounds (Box 12.1). A detailed
review of these and other major moments in the history
of plant chemical mutagenesis is given by van Harten
(1998, see Chapters 1 and 2).
There is currently an enormous number of known
chemical compounds able to induce mutations in
prokaryotic and/or eukaryotic cells and this continues
to increase. The continuous search and the synthesis of
new mutagenic compounds is driven, not by the needs
of experimental mutagenesis, but by the paradoxal fact
that several mutagenic compounds, although carcinogenic,
possess simultaneously anti-neoplastic properties
and find application in anti-tumour therapy.
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CABI Publishing