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Topical insulin meets nanomedicine: a synergy for enhanced skin regeneration

2025-07-07Artigo científico Acesso restrito
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg10:Reduzir as Desigualdades
dc.contributor.authorDuarte, Sofia O. D.
dc.contributor.authorFonte, Pedro
dc.date.accessioned2026-05-16T09:38:40Z
dc.date.available2026-05-16T09:38:40Z
dc.date.issued2025-07-07
dc.description.abstractChronic wounds, particularly those associated with diabetes, present an increasing public health burden due to their extended healing periods and high recurrence rates. One of the most common and clinically difficult forms of chronic wounds are diabetic foot ulcers, which are frequently distinguished by poor angiogenesis, ongoing inflammation, and wound environments that are rich in proteases. Over10 million people are impacted in Europe alone, with a high prevalence among those 65 and older. Over €4 billion is spent on healthcare each year, with each patient’s treatment costing between €6,000 and €10,000 [1,2]. Because of the ongoing inflammation and protease activity, conventional therapies frequently fail to promote complete regeneration, particularly in diabetic wound beds where heal-ing is severely compromised. As a result, there is now more interest in insulin, a biomolecule that is vital for wound heal-ing and has angiogenic, proliferative, and immunomodulatory qualities [2]. However, in chronic wound beds, insulin is extremely vulnerable to enzymatic degradation [3]. By encapsulating insulin in nanoparticles that resist degradation, enhance retention at the wound site, and permit con-trolled release, recent developments in nanomedicine overcome these drawbacks. These technologies better match drug availability with the changing wound environment and improve the regenerative effects of insulin [3,4]. As a result, combining topical insulin therapy with nanocarrier systems shows promise as a wound care approach, especially for diabetic ulcers and other chronic conditions.eng
dc.identifier.doi10.1080/17435889.2025.2527579
dc.identifier.eissn1748-6963
dc.identifier.issn1743-5889
dc.identifier.urihttp://hdl.handle.net/10400.1/28989
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis Group
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationInstitute for Health and Bioeconomy
dc.relation.ispartofNanomedicine
dc.rights.uriN/A
dc.subjectTopical insulin
dc.subjectNanocarriers
dc.subjectWound healing
dc.subjectDrug delivery
dc.subjectSkin regeneration
dc.subjectWound
dc.subjectPolymer
dc.subjectLipid
dc.titleTopical insulin meets nanomedicine: a synergy for enhanced skin regenerationeng
dc.typejournal article
dspace.entity.typePublication
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oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleInstitute for Health and Bioeconomy
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oaire.citation.endPage2494
oaire.citation.issue20
oaire.citation.startPage2491
oaire.citation.titleNanomedicine
oaire.citation.volume20
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFonte
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person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
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