Publicação
Antibody–drug conjugates: pharmacotherapeutic properties and future perspectives
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| datacite.subject.sdg | 17:Parcerias para a Implementação dos Objetivos | |
| dc.contributor.author | Augusto, André | |
| dc.contributor.author | Cristiano, Maria de Lurdes | |
| dc.contributor.author | Conceição, Jaime | |
| dc.date.accessioned | 2026-07-10T09:20:06Z | |
| dc.date.available | 2026-07-10T09:20:06Z | |
| dc.date.issued | 2026-04-12 | |
| dc.description.abstract | Background: The clinical landscape for antibody–drug conjugates (ADCs) is currently experiencing an unprecedented expansion, with more than 20 agents approved to date and hundreds presently under clinical evaluation, underscoring their growing impact in precision oncology. By combining the cytotoxic potency of chemotherapy with the selectivity of monoclonal antibodies, ADCs have redefined targeted cancer therapy. Nevertheless, challenges related to toxicity, resistance, and suboptimal drug delivery continue to limit their full clinical potential. Objectives: This review provides a comprehensive description of currently approved ADCs, with a particular focus on their pharmacotherapeutic properties, mechanisms of action, therapeutic indications, and safety profiles. By integrating currently available clinical data and pharmacological properties, it is possible to identify key translational gaps between ADC design and their real-world performance. This article also evaluates how the structural components contribute to both efficacy and toxicity of ADCs, offering a framework for rational molecular optimizations. Conclusions: Beyond the current oncology-centric paradigm, this review highlights the imminent pivot toward non-oncology applications, including targeted therapies for autoimmune, infectious, and neurodegenerative diseases. Importantly, this article highlights emerging innovations shaping the next generation of ADCs, including bispecific antibodies, novel cytotoxic payloads with improved therapeutic indices, and advanced linker technologies enabling more precise payload release. Despite current limitations, ongoing advances in ADC development, along with a rapidly expanding clinical pipeline, position these drugs in a dynamic therapeutic class with the potential to transform multiple complex diseases and improve the quality of life of patients who have them. | eng |
| dc.identifier.doi | 10.3390/pharmaceutics18040468 | |
| dc.identifier.issn | 1999-4923 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/29250 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.ispartof | Pharmaceutics | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Antibody–drug conjugates | |
| dc.subject | Future perspectives | |
| dc.subject | Mechanisms of action | |
| dc.subject | Pharmacotherapy | |
| dc.subject | Pharmacovigilance | |
| dc.title | Antibody–drug conjugates: pharmacotherapeutic properties and future perspectives | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 4 | |
| oaire.citation.startPage | 468 | |
| oaire.citation.title | Pharmaceutics | |
| oaire.citation.volume | 18 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Augusto | |
| person.familyName | Cristiano | |
| person.familyName | Conceição | |
| person.givenName | André | |
| person.givenName | Maria de Lurdes | |
| person.givenName | Jaime | |
| person.identifier.ciencia-id | E411-6006-5A01 | |
| person.identifier.orcid | 0009-0001-7676-4774 | |
| person.identifier.orcid | 0000-0002-9447-2855 | |
| person.identifier.orcid | 0000-0002-6201-3662 | |
| person.identifier.rid | G-2345-2012 | |
| person.identifier.scopus-author-id | 9238724800 | |
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| relation.isAuthorOfPublication | b16751a6-748e-44b0-9c59-058cbd5b2cc3 | |
| relation.isAuthorOfPublication | 6a92b338-fb98-43f8-89d0-3e02662026f8 | |
| relation.isAuthorOfPublication.latestForDiscovery | 584d2ddb-d951-47e0-bc85-775fd7edce81 |