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Mixed-valence pentadecavanadate with Ca2+-ATPase inhibition potential and anti-breast cancer activity

2025-09-12Journal article Open access
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dc.contributor.authorBrito, Bianca R.
dc.contributor.authorCamilo, Heloísa de S.
dc.contributor.authorCruz, Anderson F. da
dc.contributor.authorRibeiro, Ronny R.
dc.contributor.authorSá, Eduardo L. de
dc.contributor.authorOliveira, Carolina Camargo de
dc.contributor.authorFraqueza, Gil
dc.contributor.authorKlassen, Giseli
dc.contributor.authorAureliano, Manuel
dc.contributor.authorNunes, Giovana G.
dc.date.accessioned2025-10-16T12:21:08Z
dc.date.available2025-10-16T12:21:08Z
dc.date.issued2025-09-12
dc.description.abstractPolyoxovanadates are a subclass of polyoxometalates (POMs) known to interact with proteins and to present anticancer, antimicrobial, and antiviral activities. Herein, we aimed to pursue the study of the breast anticancer activity of a mixed-valence polyoxovanadate, [Cl@VV 7V IV 8O36] 6− (V15) against MCF-7 and MDA-MB-231 cancer cell lines and to analyze its Ca2+-ATPase inhibition potential. 51V NMR and UV-Vis/NIR studies of V15 indicated its stability in HEPES and RPMI media. For the Ca2+-ATPase activity, V15 showed an IC50 value of 14.2 µM and a mixed type of inhibition. The electrostatic potential map of V15 and other POMs were correlated with the enzyme activity inhibition. V15 also exhibited cytotoxicity against MDA-MB-231 (IC50 = 17.2 µM) and MCF-7 (IC50 = 15.1 µM) breast cancer cell lines. Using V15 concentrations equivalent to half and 1/4 of the IC50, it was observed that MDA-MB-231 cell migration was reduced by 90 and 70%, after 24 h, respectively. Moreover, V15 caused morphological changes from fusiform to an epitheliallike (amoeboid) shape. Finally, V15 induced the increase in RIPK1, MLKL, and RIPK3 gene expression, up to 3, 10, and 15-fold, respectively, pointing out that the mechanisms of cell death in the triple-negative breast cancer cell line may occur by necroptosis.eng
dc.description.sponsorshipProject No. 310107/2025-3 and 403533/2025-2) and /PRPPG/UFPR (04/2023; CNPq grant 310107/2025-3 and 403533/2025-2)
dc.identifier.doi10.3390/inorganics13090306
dc.identifier.issn2304-6740
dc.identifier.urihttp://hdl.handle.net/10400.1/27830
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofInorganics
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPolyoxometalates
dc.subjectDecavanadate
dc.subjectMixed-valence polyoxovanadates
dc.subjectP-type ATPases
dc.subjectCa2+-ATPase
dc.subjectElectrostatic potential map
dc.subjectBreast cancer
dc.subjectTriple-negative breast cancer
dc.subjectMDA-MB-231
dc.subjectMCF-7
dc.titleMixed-valence pentadecavanadate with Ca2+-ATPase inhibition potential and anti-breast cancer activityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue9
oaire.citation.startPage306
oaire.citation.titleInorganics
oaire.citation.volume13
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFraqueza
person.familyNameAureliano
person.givenNameGil
person.givenNameManuel
person.identifier1179689
person.identifier584146
person.identifier.ciencia-id1317-C7C9-5BDA
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0003-2969-9292
person.identifier.orcid0000-0003-4858-3201
person.identifier.ridA-3552-2013
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id54683851800
person.identifier.scopus-author-id6603412860
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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