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Evaluation of oxidative DNA lesions in plasma and nuclear abnormalities in erythrocytes of wild fish (Liza aurata) as an integrated approach to genotoxicity assessment

2010Journal article Restricted access
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dc.contributor.authorOliveira, M.
dc.contributor.authorAhmad, I.
dc.contributor.authorMaria, Vera L.
dc.contributor.authorFerreira, C. S. S.
dc.contributor.authorSerafim, A.
dc.contributor.authorBebianno, Maria João
dc.contributor.authorPacheco, M.
dc.contributor.authorSantos, M. A.
dc.date.accessioned2020-04-30T11:06:37Z
dc.date.available2020-04-30T11:06:37Z
dc.date.issued2010
dc.description.abstractGenetic lesions (8-hydroxy-2'-deoxyguanosine (8-OHdG) and erythrocytic nuclear abnormalities (ENA) were seasonally quantified in the blood of Liza aurata caught at Ria de Aveiro (Portugal), a multi-contaminated aquatic system. Thus, five critical sites were assessed and compared with a reference site (Torreira). Oxidative DNA damage was found in Gafanha (harbour-water area), Laranjo (metal-contaminated) and Vagos (contaminated with PAHs) in the spring; Rio Novo do Principe (near a former paper-mill effluent) in the autumn; Rio Novo do Principe and Vagos in the winter. ENA were higher than Torreira at VAG (spring and winter). Torreira did not display seasonal variation neither in terms of 8-OHdG or total ENA. A positive correlation between 8-OHdG and ENA was found, suggesting oxidative stress as a mechanism involved in the formation of ENA. This study clearly demonstrates the presence of DNA-damaging substances in Ria de Aveiro and recommends the use of 8-OHdG and ENA as biomarkers of environmental contamination.pt_PT
dc.description.sponsorshipFCT - SFRH/BPD/34326/2006pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.mrgentox.2010.08.003pt_PT
dc.identifier.issn1383-5718
dc.identifier.urihttp://hdl.handle.net/10400.1/13817
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1383571810002810?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subject8-Hydroxy-2'-deoxyguanosinept_PT
dc.subjectAnimalspt_PT
dc.subjectCell nucleus Shapept_PT
dc.subjectDeoxyguanosinept_PT
dc.subjectEnvironmental Monitoringpt_PT
dc.subjectErythrocytespt_PT
dc.subjectMicronuclei, Chromosome-Defectivept_PT
dc.subjectMutagenicity testspt_PT
dc.subjectPortugalpt_PT
dc.subjectSmegmamorphapt_PT
dc.subjectWater Pollutantspt_PT
dc.subjectDNA Damagept_PT
dc.subjectOxidative Stresspt_PT
dc.subjectLiza auratapt_PT
dc.subjectErythrocytic nuclear abnormalitiespt_PT
dc.subjectChemicalpt_PT
dc.titleEvaluation of oxidative DNA lesions in plasma and nuclear abnormalities in erythrocytes of wild fish (Liza aurata) as an integrated approach to genotoxicity assessmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FMAR%2F61195%2F2004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F27584%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F26970%2F2006/PT
oaire.citation.endPage89pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage83pt_PT
oaire.citation.titleMutation Research - Genetic Toxicology and Environmental Mutagenesispt_PT
oaire.citation.volume703pt_PT
oaire.fundingStreamPOCI
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameMaria
person.familyNamePereira Serafim
person.familyNameBebianno
person.givenNameVera Lúcia
person.givenNameMaria Angela
person.givenNameMaria
person.identifier.ciencia-id7C1D-5627-D3BC
person.identifier.ciencia-id9C18-090A-5E3D
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-0331-3489
person.identifier.orcid0000-0002-1165-0645
person.identifier.orcid0000-0003-1492-8566
person.identifier.ridI-5142-2013
person.identifier.scopus-author-id7004664869
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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