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Publication
Synthetic versus natural receptors: supramolecular control of chemical sensing in fish
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Authors
Choudhury, Rajib
Porel, Mintu
Pischel, Uwe
Jockusch, Steffen
Ramamurthy, Vaidhyanathan
Advisor(s)
Abstract(s)
The encapsulation of odorants by the synthetic receptor
cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in
Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the
olfactory receptor response to the odorant adamantan-1-amine, as
measured by electro-olfactography, was suppressed by 92% in the
presence of CB[7]. A reduction in olfactory response of 88% was
observed for pentane-1,5-diamine (cadaverine), an odorant associated with
carrion avoidance in some fish. The results reveal how the association
constants and the concentrations of natural and synthetic receptors play a
determinant role and show that synthetic receptors can be used to remove
bioactive molecules from fish olfaction.
Description
Keywords
Synthetic Natural receptors Supramolecular control Fish
Citation
José P. Da Silva, Rajib Choudhury, Mintu Porel, Uwe Pischel, Steffen Jockusch, Peter C. Hubbard,Vaidhyanathan Ramamurthy, and Adelino V. M. Canário. 2014, Synthetic versus natural receptors: supramolecular control of chemical sensing in fish, ACS Chemical Biology, 9, 1432-1436, dx.doi.org/10.1021/cb500172u
Publisher
ACS Publications