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Synthetic versus natural receptors: supramolecular control of chemical sensing in fish

2014-05-19Journal article Restricted
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dc.contributor.authorSilva, José P. da
dc.contributor.authorChoudhury, Rajib
dc.contributor.authorPorel, Mintu
dc.contributor.authorPischel, Uwe
dc.contributor.authorJockusch, Steffen
dc.contributor.authorHubbard, Peter
dc.contributor.authorRamamurthy, Vaidhyanathan
dc.contributor.authorCanario, Adelino V. M.
dc.date.accessioned2014-09-18T09:46:30Z
dc.date.available2014-09-18T09:46:30Z
dc.date.issued2014-05-19
dc.description.abstractThe encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.por
dc.description.sponsorshipGrant CTQ2011-28390 (U.P.) and by the National Science Foundation, USA, grants NSF-CHE-1111392 (S.J.) and NSFCHE- 0848017 (V.R.) are gratefully acknowledged.
dc.identifier.citationJosé P. Da Silva, Rajib Choudhury, Mintu Porel, Uwe Pischel, Steffen Jockusch, Peter C. Hubbard,Vaidhyanathan Ramamurthy, and Adelino V. M. Canário. 2014, Synthetic versus natural receptors: supramolecular control of chemical sensing in fish, ACS Chemical Biology, 9, 1432-1436, dx.doi.org/10.1021/cb500172upor
dc.identifier.doihttp://dx.doi.org/10.1021/cb500172u |
dc.identifier.issn1554-8929
dc.identifier.otherAUT: ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/4978
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherACS Publicationspor
dc.relationStrategic Project - LA 15 - 2011-2012
dc.relation.publisherversionhttp://pubs.acs.org/doi/abs/10.1021/cb500172upor
dc.subjectSyntheticpor
dc.subjectNatural receptorspor
dc.subjectSupramolecular controlpor
dc.subjectFishpor
dc.titleSynthetic versus natural receptors: supramolecular control of chemical sensing in fishpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 15 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FMAR%2FLA0015%2F2011/PT
oaire.citation.endPage1436por
oaire.citation.startPage1432por
oaire.citation.titleACS Chemical Biologypor
oaire.citation.volume9por
oaire.fundingStream6820 - DCRRNI ID
person.familyNameDa Silva
person.familyNameHubbard
person.familyNameCanario
person.givenNameJosé Paulo
person.givenNamePeter
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id3413-C4F4-73F7
person.identifier.ciencia-id951F-BA4B-A21F
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0002-6458-7328
person.identifier.orcid0000-0002-3007-4647
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridA-4606-2008
person.identifier.ridB-2823-2008
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201733236
person.identifier.scopus-author-id7005928467
person.identifier.scopus-author-id56568523700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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