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Reologia do sangue no diagnóstico clínico
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Abstract(s)
A Hemorreologia é a ciência que estuda o fluxo sanguíneo no sistema circulatório, reconhecendo a interação entre o sangue e as paredes dos vasos como a formação de um único órgão funcional. Compreender os mecanismos que influenciam esse fluxo é essencial para entender a etiologia de patologias e eventos agudos associados a alterações na viscosidade sanguínea, especialmente nos âmbitos cardíaco, cerebral e pulmonar. Os principais parâmetros hemorreológicos que determinam a viscosidade basal sanguínea, e que são úteis para diagnóstico, incluem a viscosidade plasmática, o hematócrito, a deformabilidade e a agregação eritrocitárias. Embora existam diversos métodos para o estudo desses parâmetros, a sua aplicação na rotina clínico-laboratorial ainda é limitada, com exceção da medição do hematócrito. O estudo da correlação entre alterações desses parâmetros e a clínica é crucial para diagnóstico, adequação terapêutica e prevenção, áreas nas quais a intervenção farmacêutica é fundamental em laboratórios de análises clínicas, farmácias comunitárias e hospitais. No diagnóstico, a indústria farmacêutica tem inovado com aparelhos automáticos (modelos “Succeeder”), disponíveis na Ásia, que permitem a medição direta dos parâmetros reológicos do sangue. No tratamento, terapias físicas, como ultrassonografia e cromoterapia, e novos fármacos, como o betrixabano, têm sido desenvolvidos para corrigir a viscosidade sanguínea. No entanto, ainda existem lacunas no desenvolvimento e na aplicação da Hemorreologia. As competências farmacêuticas neste campo representam uma oportunidade para melhorar os cuidados de saúde, avançar na prática profissional e oferecer uma ferramenta relevante para a saúde pública no futuro próximo.
Hemorheology is the science that studies blood flow within the circulatory system, recognizing the interaction between blood and the vessel walls as the formation of a single functional organ. Understanding the mechanisms that influence this flow is essential for understanding the aetiology of pathologies and acute events associated with changes in blood viscosity, particularly in the cardiac, cerebral, and pulmonary domains. The main hemorheological parameters that determine basal blood viscosity, and which are useful for diagnosis, include plasma viscosity, haematocrit, deformability, and erythrocyte aggregation. Although various methods exist to study these parameters, their application in routine clinical-laboratory practice remains limited, with the exception of haematocrit measurement. Studying the correlation between alterations in these parameters and clinical outcomes is crucial for diagnosis, therapeutic adjustment, and prevention, areas in which pharmaceutical intervention plays a key role in clinical analysis laboratories, community pharmacies, and hospitals. In diagnosis, the pharmaceutical industry has contributed to innovation in hemorheology with the emergence of automatic devices (such as “Succeeder” models) in Asia, which allow for direct measurement of blood rheological parameters. In treatment, physical therapies such as ultrasound and chromotherapy, as well as new drugs like Betrixaban, have been developed to correct blood viscosity. However, gaps remain in the development and application of hemorheology. Pharmaceutical expertise in this field represents an opportunity to improve healthcare, advance professional practice, and provide a relevant tool for public health in the near future.
Hemorheology is the science that studies blood flow within the circulatory system, recognizing the interaction between blood and the vessel walls as the formation of a single functional organ. Understanding the mechanisms that influence this flow is essential for understanding the aetiology of pathologies and acute events associated with changes in blood viscosity, particularly in the cardiac, cerebral, and pulmonary domains. The main hemorheological parameters that determine basal blood viscosity, and which are useful for diagnosis, include plasma viscosity, haematocrit, deformability, and erythrocyte aggregation. Although various methods exist to study these parameters, their application in routine clinical-laboratory practice remains limited, with the exception of haematocrit measurement. Studying the correlation between alterations in these parameters and clinical outcomes is crucial for diagnosis, therapeutic adjustment, and prevention, areas in which pharmaceutical intervention plays a key role in clinical analysis laboratories, community pharmacies, and hospitals. In diagnosis, the pharmaceutical industry has contributed to innovation in hemorheology with the emergence of automatic devices (such as “Succeeder” models) in Asia, which allow for direct measurement of blood rheological parameters. In treatment, physical therapies such as ultrasound and chromotherapy, as well as new drugs like Betrixaban, have been developed to correct blood viscosity. However, gaps remain in the development and application of hemorheology. Pharmaceutical expertise in this field represents an opportunity to improve healthcare, advance professional practice, and provide a relevant tool for public health in the near future.
Description
Keywords
Análises clínicas Diagnóstico Farmacêutico Hemorreologia Sangue Viscosidade sanguínea