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Brown seaweeds as a source of anti-hyaluronidase compounds

2021Journal article Restricted access
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dc.contributor.authorArunkumar, K.
dc.contributor.authorRaj, Reeshma
dc.contributor.authorRathinam, Raja
dc.contributor.authorCarvalho, Isabel S
dc.date.accessioned2021-07-12T13:34:58Z
dc.date.available2021-07-12T13:34:58Z
dc.date.issued2021
dc.description.abstractHyaluronidase enzymes disrupt hyaluronic acid, causing angiogenesis, tumor invasiveness, metastasis, inflammation, and skin aging. Phlorotannin, alginate and fucoidan were extracted successively from the blade and stipe samples of two Sargassum seaweeds and Eisenia arborea thallus. These were evaluated for their in vitro anti-hyaluronidase and antioxidant activities (DPPH and reducing power assay). The crude phlorotannin content was highest in the blade of S. tenerrimum (22.405 +/- 3.6 mu g/mg), followed by S. vulgare blade (18.385 +/- 3.29 mu g/mg) with lower amounts in the stipe portion. The highest yield of alginate and fucoidans was obtained from the blade samples of S. vulgare (0.322 +/- 0.38 and 0.198 +/- 0.016%), followed by S. tenerrimum (0.090 +/- 0.01 and 0.063 +/- 0.005%) and E. arborea thallus (0.047 +/- 0.008 and 0.032 +/- 0.003%). The sulfate content was higher in fucoidan than alginate extracted from the stipe regions of the seaweeds. Phlorotannin, fucoidan and alginate from S. vulgare, S. tenerrimum, and E. arborea possessed anti-hyaluronidase activity as evident by a decrease in the N-acetylglucosamine release. The highest anti-hyaluronidase activity was achieved in the extract of S. tennerimum blade (37.67 +/- 2.3% inhibition) due to its high phlorotannin content. Alginate and fucoidan extracted from the stipes of Sargassum species possess higher bioactivities than the blade samples. The FTIR study ascertained that alginate with a high guluronic acid and high sulfated fucoidan were extracted from the stipe samples compared to the blade samples. This increased viscosity and promoted bioactivity respectively. Further studies to evaluate the emulsifying and viscosity properties of these compounds are required before they can be considered for commercial applications.pt_PT
dc.description.sponsorshipDL 57/2016pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.sajb.2021.03.036pt_PT
dc.identifier.issn0254-6299
dc.identifier.urihttp://hdl.handle.net/10400.1/16764
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectSargassum tenerrimumpt_PT
dc.subjectSargassum vulgarept_PT
dc.subjectEisenia arboreapt_PT
dc.subjectAnti-hyaluronidasept_PT
dc.titleBrown seaweeds as a source of anti-hyaluronidase compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage477pt_PT
oaire.citation.startPage470pt_PT
oaire.citation.titleSouth African Journal of Botanypt_PT
oaire.citation.volume139pt_PT
person.familyNameRathinam
person.familyNameSaraiva de Carvalho
person.givenNameRaja
person.givenNameIsabel Maria Marques
person.identifier.ciencia-id591A-3777-B036
person.identifier.orcid0000-0002-8445-6034
person.identifier.orcid0000-0001-8057-3404
person.identifier.ridM-8564-2013
person.identifier.scopus-author-id16029399900
person.identifier.scopus-author-id35995183800
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf31fff2-143a-4f1f-ab45-7074ade0179b
relation.isAuthorOfPublicationaf26e659-578b-4e5f-a649-384cd5e4f8e3
relation.isAuthorOfPublication.latestForDiscoverycf31fff2-143a-4f1f-ab45-7074ade0179b

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