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Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function

2016Journal article Open access
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dc.contributor.authorCardoso, JoĂŁo CR
dc.contributor.authorFĂ©lix, Rute C.
dc.contributor.authorBjarnmark, Nadege
dc.contributor.authorPower, Deborah
dc.date.accessioned2017-04-07T15:56:33Z
dc.date.available2017-04-07T15:56:33Z
dc.date.issued2016
dc.description.abstractAllatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein coupled receptor (GPCR) systems share a common ancestral origin in arthropods and the vertebrates where they regulate metabolism and reproduction. The molluscs are the second most diverse phylum in the animal kingdom, they occupy an important phylogenetic position, and their genome is more similar to deuterostomes than the arthropods and nematodes and thus they are good models for studies of gene family evolution and function. This mini-review intends to extend the current knowledge about AST-A, KISS and GAL GPCR system evolution and their putative function in the mollusc mantle. Comparative evolutionary analysis of the target GPCR systems was established by identifying homologues in genomes and tissue transcriptome datasets available for molluscs and comparing them to those of other metazoan systems. Studies in arthropods have revealed the existence of the AST-A system but the loss of homologues of the KISS and GAL systems. Homologues of the insect AST-AR and vertebrate KISSR genes were found in molluscs but putative GALR genes were absent. Receptor gene number suggested that members of this family have suffered lineage specific evolution during the molluscan radiation. In molluscs, orthologues of the insect AST-A peptides were not identified but buccalin peptides that are structurally related were identified and are putative receptor agonists. The identification of AST-AR and KISSR genes in molluscs strengthens the hypotheses that in metazoans members of the AST-AR subfamily share evolutionary proximity with KISSRs. The variable number of receptors and large repertoire of buccalin peptides may be indicative of the functional diversity of the AST-AR/IGSSR systems in molluscs. The identification of AST-A and KISS receptors and ligands in the mantle transcriptome indicates that in molluscs they may have acquired a novel function and may play a role in shell development or sensory detection in the mantle.
dc.identifier.doihttp://dx.doi.org/10.1016/j.margen.2015.12.003
dc.identifier.issn1874-7787
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/9453
dc.language.isoeng
dc.peerreviewedyes
dc.relationCACHE: CAlcium in a CHanging Environment
dc.relation.isbasedonWOS:000379376100005
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAST-A and KISS GPCRs
dc.subjectEvolution
dc.subjectGenes and transcripts
dc.subjectMolluscs
dc.subjectPeptides
dc.titleAllatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCACHE: CAlcium in a CHanging Environment
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/605051/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F89811%2F2012/PT
oaire.citation.endPage35
oaire.citation.startPage25
oaire.citation.titleMarine Genomics
oaire.citation.volume27
oaire.fundingStreamFP7
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameCardoso
person.familyNamePower
person.givenNameJoĂŁo
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isProjectOfPublication4ace0b64-c18f-413a-8832-e35d6ea3815c
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