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Deciphering the role of cartilage protein 1 in human dermal fibroblasts: a transcriptomic approach

2021Journal article Restricted access
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dc.contributor.authorLetsiou, Sophia
dc.contributor.authorManchado, Manuel
dc.contributor.authorZografaki, Mariela
dc.contributor.authorMarka, Sofia
dc.contributor.authorL, Anjos
dc.contributor.authorSkliros, Dimitrios
dc.contributor.authorMartínez-Blanch, Juan F.
dc.contributor.authorFlemetakis, E.
dc.contributor.authorPower, Deborah
dc.date.accessioned2021-08-06T13:04:12Z
dc.date.available2022-07-01T00:30:14Z
dc.date.issued2021
dc.description.abstractCartilage acidic protein 1A (hCRTAC1-A) is an extracellular matrix protein (ECM) of human hard and soft tissue that is associated with matrix disorders. The central role of fibroblasts in tissue integrity and ECM health made primary human dermal fibroblasts (NHDF) the model for the present study, which aimed to provide new insight into the molecular function of hCRTAC1-A. Specifically, we explored the differential expression patterns of specific genes associated with the presence of hCRTAC1-A by RNA-seq and RT-qPCR analysis. Functional enrichment analysis demonstrated, for the very first time, that hCRTAC1-A is involved in extracellular matrix organization and development, through its regulatory effect on asporin, decorin, and complement activity, in cell proliferation, regeneration, wound healing, and collagen degradation. This work provides a better understanding of putative hCRTAC1-A actions in human fibroblasts and a fundamental insight into its function in tissue biology.pt_PT
dc.description.sponsorshipUID/Multi/04326/2020; DL57/2016/CP1361/CT0011pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s10142-021-00792-xpt_PT
dc.identifier.issn1438-793X
dc.identifier.urihttp://hdl.handle.net/10400.1/16866
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationDevelopment of Microalgae-based novel high added-value products for the Cosmetic and Aquaculture industry
dc.subjecthCRTAC1pt_PT
dc.subjectHuman fibroblastspt_PT
dc.subjectTranscriptomicspt_PT
dc.subjectECMpt_PT
dc.titleDeciphering the role of cartilage protein 1 in human dermal fibroblasts: a transcriptomic approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of Microalgae-based novel high added-value products for the Cosmetic and Aquaculture industry
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/691102/EU
oaire.citation.endPage511pt_PT
oaire.citation.issue3-4pt_PT
oaire.citation.startPage503pt_PT
oaire.citation.titleFunctional & Integrative Genomicspt_PT
oaire.citation.volume21pt_PT
oaire.fundingStreamH2020
person.familyNameAnjos Guerreiro
person.familyNamePower
person.givenNameLiliana Isabel Tomé
person.givenNameDeborah Mary
person.identifierAAK-3800-2020
person.identifier.ciencia-id6D18-2D1C-A45C
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-9474-522X
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id8575757700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication721b5dca-ad42-40f8-9731-517eb5db009e
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isProjectOfPublication2488473c-6599-4873-9885-7638817cc0d5
relation.isProjectOfPublication.latestForDiscovery2488473c-6599-4873-9885-7638817cc0d5

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