A carregar...
Publicação
Deciphering the role of cartilage protein 1 in human dermal fibroblasts: a transcriptomic approach
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.57 MB | Adobe PDF |
Autores
L, Anjos
Power, Deborah
Orientador(es)
Resumo(s)
Cartilage acidic protein 1A (hCRTAC1-A) is an extracellular matrix protein (ECM) of human hard and soft tissue that is associated with matrix disorders. The central role of fibroblasts in tissue integrity and ECM health made primary human dermal fibroblasts (NHDF) the model for the present study, which aimed to provide new insight into the molecular function of hCRTAC1-A. Specifically, we explored the differential expression patterns of specific genes associated with the presence of hCRTAC1-A by RNA-seq and RT-qPCR analysis. Functional enrichment analysis demonstrated, for the very first time, that hCRTAC1-A is involved in extracellular matrix organization and development, through its regulatory effect on asporin, decorin, and complement activity, in cell proliferation, regeneration, wound healing, and collagen degradation. This work provides a better understanding of putative hCRTAC1-A actions in human fibroblasts and a fundamental insight into its function in tissue biology.
Descrição
Palavras-chave
hCRTAC1 Human fibroblasts Transcriptomics ECM
Contexto Educativo
Citação
Editora
Springer