Bioelectrical signal detection using conducting polymer electrodes and the displacement current method

Conducting polymer electrodes based on poly (3, 4 ethylenedioxythiophene): polystyrene sulfonate were used to record electrophysiological signals from autonomous cardiac contractile cells present in embryoid bodies. Signal detection was carried out by measuring the displacement current across the polymer/electrolyte double-layer capacitance, and compared with voltage detection. While for relatively low capacitance electrodes, the voltage amplification provides higher signal quality, and for high capacitive electrodes, the displacement current method exhibits a higher signal-to-noise ratio. It is proposed that the displacement current method combined with high capacitive polymer-based electrodes is adequate to measure clusters of cells and whole organs. Our approach has a great potential in fundamental studies of drug discovery and safety pharmacology.

Palavras-chave

Embryonic Stem-Cells Microelectrode Arrays Technology Chips

URI

http://hdl.handle.net/10400.1/13084

Projetos de investigação

Implantable Organic Nano-Electronics

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Editora

Ieee-Inst Electrical Electronics Engineers Inc

DOI

10.1109/JSEN.2017.2703834

Coleções

FCB2-Artigos (em revistas ou actas indexadas)
FCT2-Artigos (em revistas ou actas indexadas)

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