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Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis

2012Journal article Restricted access
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dc.contributor.authorGomes, Tânia
dc.contributor.authorPereira, Catarina Guerreiro
dc.contributor.authorCardoso, Cátia
dc.contributor.authorPinheiro, José Paulo
dc.contributor.authorCancio, I.
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2013-12-03T14:37:01Z
dc.date.available2013-12-03T14:37:01Z
dc.date.issued2012
dc.date.updated2013-11-26T16:54:42Z
dc.description.abstractGiven the wide use of CuO nanoparticles in various industrial and commercial applications they will inevitably end up in the aquatic environment. However, little information exists on their biological effects in bivalve species. Accordingly, mussels Mytilus galloprovincialis were exposed to 10 g Cu L−1 as CuO nanoparticles and Cu2+ for 15 days, and biomarkers of oxidative stress (superoxide dismutase, catalase and glutathione peroxidase), damage (lipid peroxidation) and metal exposure (metallothionein) were determined along with Cu accumulation in the digestive glands of mussels. Cu was linearly accumulated with time of exposure in mussels exposed to CuO nanoparticles, while in those exposed to Cu2+ elimination was significant by day 15. Both forms of Cu cause oxidative stress with distinct modes of action. Exposure to CuO nanoparticles induces lower SOD activity in digestive glands compared to those exposed to Cu2+, while CAT was only activated after 7 days of exposure to nano and ionic Cu, with contradictory effects after 15 days of exposure and GPX activities were similar. Lipid peroxidation levels increased in both Cu forms despite different antioxidant efficiency. Moreover, a linear induction of metallothionein was detected with time in mussels exposed to CuO nanoparticles, directly related to Cu accumulation, whereas in those exposed to Cu2+ metallothionein was only induced after 15 days of exposure. Since only a small fraction of soluble Cu fraction was released from CuO nanoparticles, the observed effects seem to be related to the nano form of Cu, with aggregation as a key factor. Overall, our results show that the digestive gland is susceptible to CuO nanoparticles related oxidative stress, and is also the main tissue for their accumulation.por
dc.identifier.citationGomes, T.; Pereira, C. G.; Cardoso, C.; Pinheiro, J. P.; Cancio, I.; Bebianno, M. J. Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis, Aquatic Toxicology, 118-1, 118-119, 72-79, 2012.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.aquatox.2012.03.017
dc.identifier.issn0166-445X
dc.identifier.otherAUT: JPI01020; MBE00379;
dc.identifier.urihttp://hdl.handle.net/10400.1/3207
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectMytilus galloprovincialispor
dc.subjectCuO NPspor
dc.subjectOxidative stresspor
dc.subjectDigestive glandpor
dc.titleAccumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage72-79por
oaire.citation.issue1por
oaire.citation.startPage118-119por
oaire.citation.titleAquatic Toxicologypor
oaire.citation.volume118por
person.familyNameGomes
person.familyNameGuerreiro Pereira
person.familyNameCardoso
person.familyNamePinheiro
person.familyNameBebianno
person.givenNameTânia
person.givenNameCatarina Alexandra
person.givenNameCátia
person.givenNameJosé Paulo
person.givenNameMaria
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0001-6179-4543
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-3157-9898
person.identifier.orcid0000-0001-7925-9733
person.identifier.orcid0000-0003-1492-8566
person.identifier.ridI-9235-2014
person.identifier.ridE-8402-2013
person.identifier.scopus-author-id35838299700
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication71dcd70c-3a6a-45f7-bbe7-6b8a5346cc88
relation.isAuthorOfPublication164572fc-85ed-4377-afd0-7ab4c8fdc79f
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relation.isAuthorOfPublication.latestForDiscovery71dcd70c-3a6a-45f7-bbe7-6b8a5346cc88

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