Publication
Antioxidant activity and inhibitory effect of L. viridis extract on Fe2+-induced lipid peroxidation in brain homogenates
| dc.contributor.author | Costa, Patrícia | |
| dc.contributor.author | Gonçalves, Sandra | |
| dc.contributor.author | Romano, Anabela | |
| dc.date.accessioned | 2015-06-18T10:12:37Z | |
| dc.date.available | 2015-06-18T10:12:37Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | The brain is particularly susceptible to oxidative stress damaging effects due such events as the high consumption of oxygen, limited concentration of antioxidants and a relatively high degree of polyunsaturated fatty acids that are particularly good substrates for peroxidation reactions [1–3]. Oxidative stress could lead to damage biological target molecules, affecting the cellular function and integrity [4]. The ability of natural antioxidants, mainly phenolic compounds, to protect cells from oxidative stress has been previously demonstrated [5]. In this work, the methanol extract from Lavandula viridis L'Hér. (Lamiaceae), a xerophytic aromatic shrub endemic to the south-west Iberian Peninsula [6], was investigated for its effect on deoxyribose degradation, its reducing properties, Fe2+-chelating ability and total phenol content. The capacity of this extract to prevent Fe2+-induced lipid peroxidation in mouse brain (in vitro) was also evaluated. L. viridis extract showed Fe2+ chelating activity, reducing power and the ability to prevent Fe2+/H2O2-induced decomposition of deoxyribose in a dose-dependent manner. This extract also revealed a high phenol content (893.01±17.09µmol gallic acid equivalents/g extract) evaluated by Folin-Ciocalteu method. Moreover, in brain homogenates, the methanol extract of L. viridis caused a high decrease in the MDA production in both the basal and the Fe2+-induced lipid peroxidation. The effective protective properties of L. viridis could be attributed to its higher phenol content, Fe2+ chelating ability, reducing properties and HO· radical scavenging ability. The findings suggest that methanol extract from L. viridis could be a potential source of natural antioxidants. | |
| dc.identifier.doi | http://dx.doi.org/10.1055/s-0030-1264659 | |
| dc.identifier.issn | 0032-0943 | |
| dc.identifier.other | AUT: ARO01015; | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/6426 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Georg Thieme Verlag | |
| dc.relation.isbasedon | P-003-4K9 | |
| dc.title | Antioxidant activity and inhibitory effect of L. viridis extract on Fe2+-induced lipid peroxidation in brain homogenates | |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Berlin, Germany | |
| oaire.citation.endPage | 1282 | |
| oaire.citation.startPage | 1282 | |
| oaire.citation.title | Planta Medica | |
| oaire.citation.title | 7th Tannin Conference/58th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research | |
| oaire.citation.volume | 76 | |
| person.familyName | Gonçalves | |
| person.familyName | Romano | |
| person.givenName | Sandra | |
| person.givenName | Anabela | |
| person.identifier.ciencia-id | 9F19-E3AE-2C59 | |
| person.identifier.ciencia-id | 8A18-7E9A-3B0E | |
| person.identifier.orcid | 0000-0002-3038-4434 | |
| person.identifier.orcid | 0000-0002-7204-7428 | |
| person.identifier.rid | M-6988-2017 | |
| person.identifier.scopus-author-id | 8583003200 | |
| person.identifier.scopus-author-id | 56249997600 | |
| rcaap.rights | openAccess | |
| rcaap.type | conferenceObject | |
| relation.isAuthorOfPublication | a8b335b2-45cc-4578-89b0-153273014280 | |
| relation.isAuthorOfPublication | e3343b60-17d3-4f5e-a2bf-06f26da69206 | |
| relation.isAuthorOfPublication.latestForDiscovery | a8b335b2-45cc-4578-89b0-153273014280 |
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