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Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis

2019-03Journal article Restricted
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dc.contributor.authorMota, Ana Henriques
dc.contributor.authorDireito, Rosa
dc.contributor.authorCarrasco, Marta P.
dc.contributor.authorRijo, Patricia
dc.contributor.authorAscensao, Lia
dc.contributor.authorViana, Ana Silveira
dc.contributor.authorRocha, Joao
dc.contributor.authorEduardo-Figueira, Maria
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorCustódio, Luísa
dc.contributor.authorKuplennik, Nataliya
dc.contributor.authorSosnik, Alejandro
dc.contributor.authorAlmeida, Antonio Jose
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2020-07-24T10:52:40Z
dc.date.available2020-07-24T10:52:40Z
dc.date.issued2019-03
dc.description.abstractHyaluronic acid (HA) is commonly used through intra-articular administration for viscosupplementation in osteoarthritis and other disorders. HA is generally supplied as an injection commonly reported as painful, with strong limitations after treatment. In this study, an alternative delivery system was constructed based on HA hydrogel and poly(lactic-co-glycolic acid) (PLGA) particles with oleic acid. Development studies included the determination of particle toxicity, hemolytic activity, in vitro and in vivo anti-inflammatory activity using macrophages and a murine model, respectively. This study showed that empty PLGA particles presented a mean size of 373 nm, while particles containing HA and oleic acid showed a marked particle size increase. The HA association efficiency was of 73.6% and 86.2% for PLGA particles without and with oleic acid, respectively. The in vitro HA release from PLGA particles revealed a sustained profile. Particles showed a good in vitro cell compatibility and the risk of hemolysis was less < 1%, ensuring their safety. The in vivo anti-inflammatory study showed a higher inhibition for HA-loaded PLGA particles when compared to HA solution (78% versus 60%) and they were not different from the positive control, clearly suggesting that this formulation may be a promising alternative to the current HA commercial dosage form.
dc.description.sponsorshipiMed.ULisboa [UID/DTP/04138/2013]
dc.description.sponsorshipCESAM [UID/AMB/50017/2019]
dc.description.sponsorshipFCT/MEC through Portuguese funds
dc.description.sponsorshipFEDER, within the PT2020 Partnership Agreement
dc.description.sponsorshipCompete 2020
dc.identifier.doi10.1016/j.ijpharm.2019.01.017
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.urihttp://hdl.handle.net/10400.1/14389
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier Science Bv
dc.subjectDrug-delivery
dc.subjectPolymeric nanoparticles
dc.subjectNanotechnology
dc.subjectToxicity
dc.subjectHydrogel
dc.subjectDesign
dc.subjectAcne
dc.titleCombination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FDTP%2F04138%2F2013/PT
oaire.citation.endPage22
oaire.citation.startPage13
oaire.citation.titleInternational Journal of Pharmaceutics
oaire.citation.volume559
oaire.fundingStream5876
person.familyNameRodrigues
person.familyNameCustódio
person.givenNameMaria João
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
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