CYP2C8 polymorphisms among malaria patients in Guinea-Bissau

J-Lyn, Yvonne Knoo

http://hdl.handle.net/10400.1/840

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Authors

J-Lyn, Yvonne Knoo

Advisor(s)

Marques, Vera Linda Ribeiro

Abstract(s)

Cytochrome P450 (CYP) 2C8 is the major enzyme responsible for the metabolism of many clinically important drugs including the antimalarial amodiaquine (AQ). This study investigated in 91 malaria-infected patients from Guinea-Bissau, the prevalence of CYP2C8 variants CYP2C8*2, CYP2C8*3 and CYP2C8*4, which may have important clinical implications for the efficacy and toxicity of amodiaquine. CYP2C8*2 and CYP2C8*3 alleles were found to be present in high frequencies in this population at 24% and 32%, respectively. Most of the subjects analysed were carriers of at least one variant allele. This suggests the possibility of a high occurrence of CYP2C8 poor metabolizer individuals among malaria patients in Guinea-Bissau, who may therefore be at a greater risk of adverse effects compared to other populations previously characterized.