Publication
CYP2C8 polymorphisms among malaria patients in Guinea-Bissau
| dc.contributor.advisor | Marques, Vera Linda Ribeiro | |
| dc.contributor.author | J-Lyn, Yvonne Knoo | |
| dc.date.accessioned | 2011-09-07T16:05:43Z | |
| dc.date.available | 2011-09-07T16:05:43Z | |
| dc.date.issued | 2008-04-16 | |
| dc.date.submitted | 2008 | |
| dc.description | Tese mest. , Gestão da Água e da Costa, 2008, Universidade do Algarve | por |
| dc.description.abstract | Cytochrome P450 (CYP) 2C8 is the major enzyme responsible for the metabolism of many clinically important drugs including the antimalarial amodiaquine (AQ). This study investigated in 91 malaria-infected patients from Guinea-Bissau, the prevalence of CYP2C8 variants CYP2C8*2, CYP2C8*3 and CYP2C8*4, which may have important clinical implications for the efficacy and toxicity of amodiaquine. CYP2C8*2 and CYP2C8*3 alleles were found to be present in high frequencies in this population at 24% and 32%, respectively. Most of the subjects analysed were carriers of at least one variant allele. This suggests the possibility of a high occurrence of CYP2C8 poor metabolizer individuals among malaria patients in Guinea-Bissau, who may therefore be at a greater risk of adverse effects compared to other populations previously characterized. | |
| dc.format | application/pdf | por |
| dc.identifier.uri | http://hdl.handle.net/10400.1/840 | |
| dc.language.iso | eng | por |
| dc.subject | Teses | por |
| dc.subject | Malária | por |
| dc.subject | Polimorfismo | por |
| dc.subject | Amodiaquina | por |
| dc.subject | Citocromo | por |
| dc.subject | 616.9 | por |
| dc.title | CYP2C8 polymorphisms among malaria patients in Guinea-Bissau | por |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | restrictedAccess | |
| rcaap.type | masterThesis | por |
| thesis.degree.grantor | Universidade do Algarve. Faculdade de Ciências e Tecnologia | |
| thesis.degree.level | Mestre | |
| thesis.degree.name | Mestrado em Gestão da Água e da Costa |