Editorial: tissue crosstalk in obesity and diabetes: a focus on skeletal muscle

De Sousa-Coelho, Ana Luísa; Estêvão, Maria Dulce da Mota Antunes de Oliveira; Patti, Mary Elizabeth; Lerin, Carles

http://hdl.handle.net/10400.1/28062

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Authors

De Sousa-Coelho, Ana Luísa

Estêvão, Maria Dulce da Mota Antunes de Oliveira

Patti, Mary Elizabeth

Lerin, Carles

Abstract(s)

In the complex biological system of higher organisms, the maintenance of metabolic homeostasis requires intricate crosstalk among different tissues and organs. Such inter-organ communication, including classical hormones, other peptides, and extracellular vesicles (EVs), allows one tissue to affect metabolic pathways in a distant tissue. Dysregulation of this communication contributes to human pathologies, including obesity, diabetes, liver diseases, and certain cancers. This Research Topic aimed to shed light onto the complex tissue crosstalk underlying metabolic diseases, specifically obesity and type 2 diabetes (T2D). It highlights the latest scientific evidence exploring such interactions among different tissues, with a specific focus on the role of skeletal muscle and its secretion of myokines and EVs that contribute to the regulation of metabolism in liver, adipose tissue, and other organs.