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Polyoxovanadate inhibition of Escherichia coli growth shows a reverse correlation with Ca2+-ATPase inhibition

2019-12Journal article Restricted
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dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorFraqueza, Gil
dc.contributor.authorLagoa, Ricardo
dc.contributor.authorVannathan, Anjana Anandan
dc.contributor.authorMal, Sib Sankar
dc.contributor.authorAureliano, Manuel
dc.date.accessioned2020-07-24T10:50:44Z
dc.date.available2020-07-24T10:50:44Z
dc.date.issued2019-12
dc.description.abstractRecently, a global analysis of the structure-activity-relationship of a series of polyoxometalates (POMs) revealed that the most active POMs were ascribed to be polyoxovanadates (POVs), especially decavanadate (V-10), which was very active against certain bacteria (Bijelic et al., Chem. Commun., 2018). The present study explores this observation and compares the effects of three POVs namely MnV11, MnV13 and V-10 against Escherichia coli growth. It was observed that MnV11 presents the lowest growth inhibition (GI(50)) value for Escherichia coli followed by the MnV13 compound, being about 2 times lower than that of V-10 respectively, the values obtained were 0.21, 0.27 and 0.58 mM. All three compounds were more effective than vanadate alone (GI(50) = 1.1 mM) and also than decaniobate, Nb-10 (GI(50) > 10 mM), an isostructural POM of V-10. However, the POVs exhibiting the highest antibacterial activity (MnV11) were shown to have the lowest Ca2+-ATPase inhibitor capacity (IC50 = 58 mM) whereas decavanadate, which was also very active against this membranar ATPase (IC50 = 15 mM), was less active against bacterial growth, suggesting that POV inhibition of ion pumps might not be associated with the inhibition of Escherichia coli growth.
dc.description.sponsorshipCouncil of Scientific & Industrial Research (CSIR)Council of Scientific & Industrial Research (CSIR) - India [01(2906)/17/EMR-II]
dc.identifier.doi10.1039/c9nj01208g
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.urihttp://hdl.handle.net/10400.1/14146
dc.language.isoeng
dc.peerreviewedyes
dc.publisherRoyal Society of Chemistry
dc.subjectAntibacterial activity
dc.subjectDecavanadate interactions
dc.subjectPolyoxometalate
dc.subjectVanadate
dc.subjectComplex
dc.subjectBinding
dc.subjectPolyoxotungstates
dc.subjectDecaniobate
dc.subjectAntitumor
dc.subjectPeptides
dc.titlePolyoxovanadate inhibition of Escherichia coli growth shows a reverse correlation with Ca2+-ATPase inhibition
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.citation.endPage17587
oaire.citation.issue45
oaire.citation.startPage17577
oaire.citation.titleNew Journal of Chemistry
oaire.citation.volume43
oaire.fundingStream5876
person.familyNameFraqueza
person.familyNameAureliano
person.givenNameGil
person.givenNameManuel
person.identifier1179689
person.identifier584146
person.identifier.ciencia-id1317-C7C9-5BDA
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0003-2969-9292
person.identifier.orcid0000-0003-4858-3201
person.identifier.ridA-3552-2013
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id54683851800
person.identifier.scopus-author-id6603412860
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication9e7ef53d-b79c-4446-9093-0611980e6ecd
relation.isAuthorOfPublicationbb413661-7edd-4b57-8338-33889cfd05db
relation.isAuthorOfPublication.latestForDiscovery9e7ef53d-b79c-4446-9093-0611980e6ecd
relation.isProjectOfPublication868b4818-3efa-4edb-9202-c464d64fd38f
relation.isProjectOfPublication.latestForDiscovery868b4818-3efa-4edb-9202-c464d64fd38f

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