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Publication
Estatinas- passado, presente e futuro na terapĂȘutica
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Advisor(s)
Abstract(s)
As estatinas apresentam um papel relevante na ĂĄrea cardiovascular e tĂȘm-se evidenciado um crescimento da sua utilização. No contexto cardiovascular, diversos estudos evidenciaram que a classe terapĂȘutica das estatinas diminuem o nĂvel sĂ©rico do colesterol de baixa densidade, por inibição da enzima hidroxi-metil-glutaril-CoA redutase. As variantes genĂ©ticas presentes nos doentes podem ser importantes para o resultado clĂnico da terapia com estatinas, afetando a sua eficĂĄcia e segurança. Estes resultados devem, no entanto, ser interpretados com precaução e Ă© necessĂĄrio uma avaliação do risco/beneficio. Os efeitos adversos associados ao uso das estatinas encontram-se a nĂvel do mĂșsculo-esquelĂ©tico, a efeitos metabĂłlicos, neurolĂłgicos e outros. No entanto, as estatinas tambĂ©m se apresentam como opção no tratamento de outras doenças, como por exemplo na ĂĄrea oncolĂłgica.
Statins play an important role in the cardiovascular area and an increase in their use has been shown. In the cardiovascular context, several studies have shown that the therapeutic class of statins not only lowering the serum level of low-density cholesterol by inhibiting the hydroxy-methyl-glutaryl-CoA reductase enzyme. Genetic variants present in patients may be important for the clinical outcome of statin therapy, affecting its efficacy and safety. These results should, however, be interpreted with caution and a risk/benefit assessment. Adverse effects associated with the use of statins, are at level of musculoskeletal, metabolic, neurological and others. However, statins are also an option in treatment of others disease, such as in oncology.
Statins play an important role in the cardiovascular area and an increase in their use has been shown. In the cardiovascular context, several studies have shown that the therapeutic class of statins not only lowering the serum level of low-density cholesterol by inhibiting the hydroxy-methyl-glutaryl-CoA reductase enzyme. Genetic variants present in patients may be important for the clinical outcome of statin therapy, affecting its efficacy and safety. These results should, however, be interpreted with caution and a risk/benefit assessment. Adverse effects associated with the use of statins, are at level of musculoskeletal, metabolic, neurological and others. However, statins are also an option in treatment of others disease, such as in oncology.
Description
Keywords
Colesterol Dislipidemia Doença cardiovascular e estatinas