Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/6519
Título: Chemical mutagenesis
Autor: Leitão, José
Data: 2012
Editora: CABI Publishing
Resumo: The first attempts to induce mutations in biological systems using chemical compounds go back to the beginning of the past century. However, it was during World War II that the two most relevant names in chemical mutagenesis, Charlotte Auerbach and Iosif A. Rapoport, established the mutagenic properties of several chemical compounds (Box 12.1). A detailed review of these and other major moments in the history of plant chemical mutagenesis is given by van Harten (1998, see Chapters 1 and 2). There is currently an enormous number of known chemical compounds able to induce mutations in prokaryotic and/or eukaryotic cells and this continues to increase. The continuous search and the synthesis of new mutagenic compounds is driven, not by the needs of experimental mutagenesis, but by the paradoxal fact that several mutagenic compounds, although carcinogenic, possess simultaneously anti-neoplastic properties and find application in anti-tumour therapy.
URI: http://hdl.handle.net/10400.1/6519
ISBN: 9781780640853
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