Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/6739
Título: Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins
Autor: Fernandes, A.
Rosa da Costa, Ana
Serra, Arménio C.
Pires, Catarina
Palavras-chave: Catalytic transfer reduction
hydrogenation
Meso-tetraphenylchlorin
Meso-tetraphenylporphyrin
Photosensitizers
Data: Abr-2011
Editora: Medknow
Citação: J Pharm Bioall Sci 2011;3:294-7
Resumo: A number of new porphyrin-based photosensitizers have been developed for Photodynamic Therapy (PDT) in recent years. Chlorins, which are a reduced form of porphyrins, show better potential of application since they have a stronger absorption band on the red region of the visible spectrum and, hence, a deeper penetration into tissues. We found that by using heterogeneous catalytic transfer reduction (CTR), meso-tetraphenylporphyrin (TPP) could be hydrogenated, although in modest yields, to meso-tetraphenylchlorin (TPC) in a single reaction step. Best reaction conditions were attained using formic acid or sodium phosphinate/water as hydrogen donors, tetrahydrofuran (THF) or toluene as solvent and 10% palladium on charcoal as catalyst.
Peer review: yes
URI: http://hdl.handle.net/10400.1/6739
DOI: 10.4103/0975-7406.80770
ISSN: 0976-4879
Versão do Editor: http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=2;spage=294;epage=297;aulast=Brigas
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)

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