FCT2-Artigos (em revistas ou actas indexadas)
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Percorrer FCT2-Artigos (em revistas ou actas indexadas) por Objetivos de Desenvolvimento Sustentável (ODS) "03:Saúde de Qualidade"
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- Adaptation and validation of the perceived restorativeness scale (PRS) for the portuguese population: a study on the assessment of the restorative effect of environmentsPublication . Sousa, Cátia; Silva Fernandes, Maria Jacinta; Encarnação, Tiago; Gonçalves, GabrielaThe relationship between natural environments and psychological well-being has gained increasing attention in environmental and health sciences. However, there is still a lack of robust quantitative instruments to assess the restorative potential of different environments. This study aimed to adapt and validate the Portuguese version of the Perceived Restorativeness Scale (PRS), an instrument based on Attention Restoration Theory that evaluates the perceived restorative qualities of environments. In Study 1, exploratory and confirmatory factor analyses were conducted on data from 410 participants. The results supported a refined 20-item version of the scale, comprising four factors—being away, fascination, compatibility, and legibility—with good internal consistency and acceptable model fit. Measurement invariance analysis confirmed configural, metric, and scalar invariance across gender. In Study 2, a separate sample of 212 participants completed the PRS along with additional validated measures: the Sublime Emotion toward Nature Scale (SEN), an aesthetic evaluation of landscapes, and the Positive and Negative Affect Schedule (PANAS). The PRS showed strong convergent and discriminant validity and significantly predicted restorative outcomes. These findings support the psychometric adequacy of the Portuguese PRS and its relevance as a valid tool for assessing perceived restorativeness in both natural and built environments. The scale may inform future research and public policies aimed at designing spaces that promote psychological restoration and mental well-being.
- Advanced nanotherapeutic strategies transforming diabetic wound healingPublication . Ramos, Filipa; Kumar, Girish; Virmani, Tarun; Sharma, Abhishek; Duarte, Sofia O. D.; Fonte, PedroDue to their high recurrence rates and slow healing, diabetic wounds are becoming a greater public health concern [Citation1]. Each year, 1.6 million cases of diabetic wounds occur in the United States alone, affecting approximately 18.6 million people worldwide [Citation2]. Because of poor cellular regeneration, increased inflammation, and reduced angiogenesis, traditional treatments like debridement, antibiotics, and dressings usually do not work [Citation3]. To overcome the limitations of traditional treatments, there is now a significant demand for advanced therapeutic modalities that promise accurate, efficient, and rapid healing processes [Citation4]. These include microneedles (MNs), exosomes, tetrahedral framework nucleic acids (tFNAs), three-dimensional scaffolds, gene therapy, oxygen-releasing biomaterials, phototherapies, and nanozymes.
- Antibacterial, antioxidant, and antiproliferative activities of corymbia citriodora and the essential oils of eight eucalyptus speciesPublication . Miguel, Maria da Graça; Gago, Custódia; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Lagoas, Soraia; Faleiro, Maria Leonor; Megías, Cristina; Cortés-Giraldo, Isabel; Vioque, Javier; Figueiredo, Ana CristinaBackground: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+• ) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC). Antibacterial activity was evaluated using the microorganisms Streptococcus pneumoniae (strains D39 and TIGR4), and Haemophilus influenza (strain DSM 9999). The essential oils’ minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was assessed using a microdilution method. The antiproliferative activity was determined using the THP-1 cell line (human acute monocytic leukaemia) with methylthiazolyldiphenyl-tetrazolium bromide assay (MTT). Results: Corymbia citriodora and Eucalyptus viminalis EOs showed the highest ABTS and peroxyl free radical scavenging capacity. Eucalyptus globulus EO showed a high potential to treat Streptococcus pneumoniae infections. Haemophilus influenzae was the respiratory pathogen that showed the highest resistance to all EOs, including tea tree EO. After 96 h of incubation, at 25 µg/mL, Eucalyptus radiata and Eucalyptus viminalis EOs showed highest cytotoxic activity against the THP-1 cell line. Conclusions: Despite their specific bioactivities, no single EO showed simultaneously good antioxidant, antimicrobial, and antiproliferative activity.
- Antimicrobial and antioxidant activities of natural compounds: enhance the safety and quality of foodPublication . Faleiro, Maria Leonor; Miguel, Maria da GraçaNature has offered us a tremendous diversity of natural compounds, for which antimicrobial and antioxidant properties have been intensively explored and nowadays are plenty recognized. During the last decades both the antimicrobial action of natural compounds (preventing and limiting microbial growth) and their antioxidant properties (reducing the oxidation of fats and limiting the ripening and browning of fruit and vegetables after harvesting) have been intensively investigated, particularly in the food packaging sector, evidencing that they may represent an effective eco-friendly approach to enhance the safety and quality of food products, without an environmentally deleterious impact.
- Antioxidant activity of myrtus communis l. and myrtus nivellei batt. & trab. extracts: a brief reviewPublication . Hennia, Aicha; Miguel, Maria da Graça; Nemmiche, SaidMyrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids. In coloured berries, anthocyanins are also present. In M. nivellei extracts are reported for some compounds not described in M. communis so far: 2-hydroxy-1,8-cineole-β-D-glucopyranoside, 2-hydroxy-1,8-cineole 2-O-α-L-arabinofuranosyl (1→6)-β-D-glucopyranoside, rugosin A, and rugosin B. Berries and leaves extracts of both species had antioxidant activity. Comparative studies of the antioxidant activity between leaf and berry myrtle extracts revealed that leaf extracts are best antioxidants, which can be assigned to the galloyl derivatives, flavonols, and flavonols derivatives, although the ratio of these groups of compounds might also have an important role in the antioxidant activity. The anthocyanins present in myrtle berries seem to possess weak antioxidant activity. The antioxidant activity of sample extracts depended on various factors: harvesting time, storage, extraction solvent, extraction type, and plant part used, among other factors. Leaf extracts of myrtle revealed to possess anti-inflammatory activity in several models used. This property has been attributed either to the flavonoids and/or hydrolysable tannins, nevertheless nonprenylated acylphloroglucinols (e.g., myrtucommulone and semimyrtucommulone) have also revealed a remarkable role in that activity. The biological activities of myrtle extracts found so far may direct its use towards for stabilizing complex lipid systems, as prebiotic in food formulations, and as novel therapeutic for the management of inflammation.
- Diversity of bioactive compounds in microalgae: key classes and functional applicationsPublication . Osathanunkul, Maslin; Thanaporn, Suebsuya; Karapetsi, Lefkothea; Nteve, Georgia Maria; Pratsinakis, Emmanouil; Stefanidou, Eleni; Lagiotis, Giorgos; Avramidou, Eleni; Zorxzobokou, Lydia; Tsintzou, Georgia; Athanasiou, Artemis; Mpelai, Sofia; Constandinidis, Constantinos; Pantiora, Panagiota; Merino, Marián; Mullor, José Luis; Dobrovic, Luka; Cerasino, Leonardo; Ogawa, Tomohisa; Tsaousi, Meropi; Rodrigues, Alexandre M. C.; Cardoso, Helena; Pires, Rita; Rodrigues Figueiredo, Daniel; Figueiredo, Daniel; Costa, Inês F.; Anjos, Catarina; Labrou, Nikolaos E.; Madesis, PanagiotisMicroalgae offer a sustainable and versatile source of bioactive compounds. Their rapid growth, efficient CO2 utilization, and adaptability make them a promising alternative to traditional production methods. Key compounds, such as proteins, polyunsaturated fatty acids (PUFAs), polyphenols, phytosterols, pigments, and mycosporine-like amino acids (MAAs), hold significant commercial value and are widely utilized in food, nutraceuticals, cosmetics, and pharmaceuticals, driving innovation across multiple industries. Their antiviral and enzyme-producing capabilities further enhance industrial and medical applications. Additionally, microalgae-based biostimulants and plant elicitor peptides (PEPs) contribute to sustainable agriculture by enhancing plant growth and resilience to environmental stressors. The GRAS status of several species facilitates market integration, but challenges in scaling and cost reduction remain. Advances in biotechnology and metabolic engineering will optimize production, driving growth in the global microalgae industry. With increasing consumer demand for natural, eco-friendly products, microalgae will play a vital role in health, food security, and environmental sustainability.
- Embedding a real-time strawberry detection model into a pesticide-spraying mobile robot for greenhouse operationPublication . Amraoui, Khalid El; Ansari, Mohamed El; Lghoul, Mouataz; Alaoui, Mustapha El; Abanay, Abdelkrim; Jabri, Bouazza; Masmoudi, Lhoussaine; LUÍS VALENTE DE OLIVEIRA, JOSÉAbstract: The real-time detection of fruits and plants is a crucial aspect of digital agriculture, enhancing farming efficiency and productivity. This study addresses the challenge of embedding a real-time strawberry detection system in a small mobile robot operating within a greenhouse environment. The embedded system is based on the YOLO architecture running in a single GPU card, with the Open Neural Network Exchange (ONNX) representation being employed to accelerate the detection process. The experiments conducted in this study demonstrate that the proposed model achieves a mean average precision (mAP) of over 97%, processing eight frames per second for 512 × 512 pixel images. These results affirm the utility of the proposed approach in detecting strawberry plants in order to optimize the spraying process and avoid inflicting any harm on the plants. The goal of this research is to highlight the potential of integrating advanced detection algorithms into small-scale robotics, providing a viable solution for enhancing precision agriculture practices.
- Euphorbia resinifera: chemical composition and biological properties (short review)Publication . boutoub, Oumaima; Ghadraoui, Lahsen El; Miguel, Maria da GraçaThis review updates the information on the chemical composition of E. resinifera (spurge resin) latex and its biological properties, as well as those from the aerial parts and bee products (honey and propolis), generally without latex. From such review and according to the studies developed so far, it was possible to confirm that the chemical composition of latex and non-latex compounds differs. In the latex, diterpenes, nor sesquiterpenes, triterpenes, and serine proteases (EuRP-61) with 61 kDa predominate despite other minor compounds. The identified protease had anticoagulant, antiplatelet, and peripheral blood cell aggregation inhibitory properties. Phenolics, including flavonoids and tannins, have antioxidant activity and are dominant in the aerial parts of E. resinifera. Phenolic acids and flavonoids, particularly flavanones, flavones, and flavonols and their glycosides, were identified in the spurge resin honey. Generally, honey samples were within the acceptable limit of international standards. Antioxidant activity was reported for this monofloral honey. Antimicrobial activity was also detected in hydroalcoholic extracts of propolis.
- Evaluation of biogenic amine and free fatty acid profiles during the manufacturing process of traditional dry-cured tunaPublication . Sánchez-Parra, Mónica; Lopez, Annalaura; Ordóñez-Díaz, José Luis; Rodríguez Solana, Raquel; Montenegro-Gómez, José Carlos; Pérez-Aparicio, Jesús; Moreno-Rojas, José ManuelThe aim of this study was to investigate the changes in the formation of biogenic amines and free fatty acids occurring during the manufacturing process of a traditional dry-cured product based on yellowfin tuna, Thunnus albacares (protected geographical indication—Mojama) and how the different processing stages could affect food safety aspects. The biogenic amines profile was determined by HPLC–DAD, following the official methodology, and free fatty acids were quantified by GC–MS. Histamine levels found in all stages of the manufacturing process did not exceed the maximum limits established in the European Commission (100–200 mg/kg) and US Food and Drug Administration (50 mg/kg) regulations. Other biogenic amines, such as cadaverine and putrescine, were detected at low level or below the limit of detection. Yellowfin tuna filets could be classified as lean fish flesh, presenting 1.18% fat on average. An increment in the free fatty acid fraction was evidenced along the manufacturing process, ranging from 10.37% of the total lipids in fresh loins to 16.88% in the dry-cured filet product. The results indicated that the traditional manufacturing process of mojama, consisting of salting and drying tuna loins kept at a controlled temperature, promoted a moderate lipolysis phenomenon, and the formation of free fatty acids with high proportions of unsaturated fatty acids, likely arising from the lipolysis of muscle phospholipids.
- Evaluation of hydro-geochemical processes controlling groundwater quality in Balkh center (Mazar-e-Sharif), northern AfghanistanPublication . Farahmand, Asadullah; Zaryab, Abdulhalim; Ameri, Nasrullah; Ali, Shakir; Eqrar, Mohammad NaimBackground: Groundwater in Afghanistan stands as the predominant water source employed for potable consumption, household utilization, irrigation, and industrial applications. Major cities of Afghanistan are largely dependent on groundwater resources. However, the groundwater quality of major cities in Afghanistan, including Mazar-e-Sharif city was not investigated in detail. Objective: This study aims to conduct a comprehensive analysis of the hydrochemical characteristics of the Mazare-Sharif groundwater, identify the factors influencing groundwater quality, and evaluate the groundwater contamination sources. Methods: A total of 18 groundwater samples were collected during the dry season (June 2020) and analyzed for various physico-chemical parameters. Methods such as multivariate statistical analyses, geochemical modeling, water quality index (WQI), and spatial distribution of groundwater quality were employed to evaluate the hydrogeochemistry of the study area. Results: The results reveal that 1) The prevailing groundwater within the study area is predominantly characterized by Na-(Ca)-HCO3 and Ca-(Mg)-SO4 water types. 2) Physicochemical variables such as NO3 − , F− , TDS, and SO4 2− exceeded the World Health Organization (WHO) safe limits in many wells. 3) Hydro-geochemical processes such as silicate weathering, cation exchange, and gypsum dissolution controls the groundwater chemistry. 4) Cl/ Br ratios reveal, that high salinity may originate from evaporitic lacustrine and evaporite deposits and found to be localized in nature. 5) The Water Quality Index (WQI) classification suggests that approximately 60 % of the groundwater samples fall into poor to very poor water quality categories, highlighting substantial public health concerns. Major contaminants like nitrate and fluoride were found to be higher than the safe limit in nearly half of the samples. Conclusion: The findings of this study hold value for decision-makers in formulating a proficient strategy for the management of groundwater resources in Mazar-e-Sharif City in achieving the UN sustainable goal (SDG) of providing sustainable water for all. Furthermore, new advanced techniques like environmental isotopes should be analyzed to evaluate groundwater hydro-chemical evolution in the future to enhance our understanding.