FCT2-Artigos (em revistas ou actas indexadas)
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Percorrer FCT2-Artigos (em revistas ou actas indexadas) por Objetivos de Desenvolvimento Sustentável (ODS) "03:Saúde de Qualidade"
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- Adaptation and validation of the perceived restorativeness scale (PRS) for the portuguese population: a study on the assessment of the restorative effect of environmentsPublication . Sousa, Cátia; Silva Fernandes, Maria Jacinta; Encarnação, Tiago; Gonçalves, GabrielaThe relationship between natural environments and psychological well-being has gained increasing attention in environmental and health sciences. However, there is still a lack of robust quantitative instruments to assess the restorative potential of different environments. This study aimed to adapt and validate the Portuguese version of the Perceived Restorativeness Scale (PRS), an instrument based on Attention Restoration Theory that evaluates the perceived restorative qualities of environments. In Study 1, exploratory and confirmatory factor analyses were conducted on data from 410 participants. The results supported a refined 20-item version of the scale, comprising four factors—being away, fascination, compatibility, and legibility—with good internal consistency and acceptable model fit. Measurement invariance analysis confirmed configural, metric, and scalar invariance across gender. In Study 2, a separate sample of 212 participants completed the PRS along with additional validated measures: the Sublime Emotion toward Nature Scale (SEN), an aesthetic evaluation of landscapes, and the Positive and Negative Affect Schedule (PANAS). The PRS showed strong convergent and discriminant validity and significantly predicted restorative outcomes. These findings support the psychometric adequacy of the Portuguese PRS and its relevance as a valid tool for assessing perceived restorativeness in both natural and built environments. The scale may inform future research and public policies aimed at designing spaces that promote psychological restoration and mental well-being.
- Advanced nanotherapeutic strategies transforming diabetic wound healingPublication . Ramos, Filipa; Kumar, Girish; Virmani, Tarun; Sharma, Abhishek; Duarte, Sofia O. D.; Fonte, PedroDue to their high recurrence rates and slow healing, diabetic wounds are becoming a greater public health concern [Citation1]. Each year, 1.6 million cases of diabetic wounds occur in the United States alone, affecting approximately 18.6 million people worldwide [Citation2]. Because of poor cellular regeneration, increased inflammation, and reduced angiogenesis, traditional treatments like debridement, antibiotics, and dressings usually do not work [Citation3]. To overcome the limitations of traditional treatments, there is now a significant demand for advanced therapeutic modalities that promise accurate, efficient, and rapid healing processes [Citation4]. These include microneedles (MNs), exosomes, tetrahedral framework nucleic acids (tFNAs), three-dimensional scaffolds, gene therapy, oxygen-releasing biomaterials, phototherapies, and nanozymes.
- Antibacterial, antioxidant, and antiproliferative activities of corymbia citriodora and the essential oils of eight eucalyptus speciesPublication . Miguel, Maria da Graça; Gago, Custódia; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Lagoas, Soraia; Faleiro, Maria Leonor; Megías, Cristina; Cortés-Giraldo, Isabel; Vioque, Javier; Figueiredo, Ana CristinaBackground: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+• ) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC). Antibacterial activity was evaluated using the microorganisms Streptococcus pneumoniae (strains D39 and TIGR4), and Haemophilus influenza (strain DSM 9999). The essential oils’ minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was assessed using a microdilution method. The antiproliferative activity was determined using the THP-1 cell line (human acute monocytic leukaemia) with methylthiazolyldiphenyl-tetrazolium bromide assay (MTT). Results: Corymbia citriodora and Eucalyptus viminalis EOs showed the highest ABTS and peroxyl free radical scavenging capacity. Eucalyptus globulus EO showed a high potential to treat Streptococcus pneumoniae infections. Haemophilus influenzae was the respiratory pathogen that showed the highest resistance to all EOs, including tea tree EO. After 96 h of incubation, at 25 µg/mL, Eucalyptus radiata and Eucalyptus viminalis EOs showed highest cytotoxic activity against the THP-1 cell line. Conclusions: Despite their specific bioactivities, no single EO showed simultaneously good antioxidant, antimicrobial, and antiproliferative activity.
- Antimicrobial and antioxidant activities of natural compounds: enhance the safety and quality of foodPublication . Faleiro, Maria Leonor; Miguel, Maria da GraçaNature has offered us a tremendous diversity of natural compounds, for which antimicrobial and antioxidant properties have been intensively explored and nowadays are plenty recognized. During the last decades both the antimicrobial action of natural compounds (preventing and limiting microbial growth) and their antioxidant properties (reducing the oxidation of fats and limiting the ripening and browning of fruit and vegetables after harvesting) have been intensively investigated, particularly in the food packaging sector, evidencing that they may represent an effective eco-friendly approach to enhance the safety and quality of food products, without an environmentally deleterious impact.
- Antioxidant activity of myrtus communis l. and myrtus nivellei batt. & trab. extracts: a brief reviewPublication . Hennia, Aicha; Miguel, Maria da Graça; Nemmiche, SaidMyrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids. In coloured berries, anthocyanins are also present. In M. nivellei extracts are reported for some compounds not described in M. communis so far: 2-hydroxy-1,8-cineole-β-D-glucopyranoside, 2-hydroxy-1,8-cineole 2-O-α-L-arabinofuranosyl (1→6)-β-D-glucopyranoside, rugosin A, and rugosin B. Berries and leaves extracts of both species had antioxidant activity. Comparative studies of the antioxidant activity between leaf and berry myrtle extracts revealed that leaf extracts are best antioxidants, which can be assigned to the galloyl derivatives, flavonols, and flavonols derivatives, although the ratio of these groups of compounds might also have an important role in the antioxidant activity. The anthocyanins present in myrtle berries seem to possess weak antioxidant activity. The antioxidant activity of sample extracts depended on various factors: harvesting time, storage, extraction solvent, extraction type, and plant part used, among other factors. Leaf extracts of myrtle revealed to possess anti-inflammatory activity in several models used. This property has been attributed either to the flavonoids and/or hydrolysable tannins, nevertheless nonprenylated acylphloroglucinols (e.g., myrtucommulone and semimyrtucommulone) have also revealed a remarkable role in that activity. The biological activities of myrtle extracts found so far may direct its use towards for stabilizing complex lipid systems, as prebiotic in food formulations, and as novel therapeutic for the management of inflammation.
- Antioxidant and a-amylase inhibition activities of six plants used in the management of diabetes in MoroccoPublication . Aazza, Smail; El-Guendouz, Soukaina; Miguel, Maria da GraçaDiabetes mellitus is one of the major health problems in the world. Conventional antidiabetic drugs are effective; however, they also with unavoidable side effects. On the other hand, plants may be an alternative source of antidiabetic agents. In the present study, six plants (Cynara scolymus, Ceratonia siliqua, Centaurium erythraea, Marrubium vulgare, Salvia officinalis, and Ziziphus lotus reputed for their antidiabetic effect in Moroccan traditional medicine were chosen. The work was focused on the determination of the antioxidant activities by several methods, including as well as their -amylase inhibitory capacity. It was noted that S. officinalis extract contained the highest phenolic contents and the strongest ABTS and nitric oxide scavenging activities. C. erythraea has the highest total flavonoid content and the best total antioxidant activity. M. vulgare showed the best -amylase inhibitory activity and the best chelating power abreast with C. scolymus, which presented very weak antioxidant activities unless good -amylase inhibition. Principal component analysis (PCA) showed a very good correlation between total phenolic content and 2,2-diphenyl-1-picrylhydrazyl (DPPH) along with 2,2'-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals scavenging activities. M. vulgare displayed the best α-amylase inhibition capacity.
- Development of a novel formulation of a functional tomato saucePublication . Ngameni Tchonkouang, Rose Daphnee; Martey, Dorcas Martekie; Bal, Murad; Oztop, Mecit Halil; Gago, Custódia; Guerreiro, Adriana; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Vieira, MargaridaA functional tomato sauce was developed through the enrichment of high-lycopene tomato pulp (TomP) with pea protein (PP), freeze-dried olive powder (OP), and tomato peel powder (TPP) to achieve good sensory acceptability and a high antioxidant level using a 4-component (X1-TomP, X2-PP, X3-OP, X4-TPP) D-optimal mixture design. Responses: Y1-color, Y2-aspect, Y3-aroma, Y4-flow/texture, Y5-taste, Y6-sourness, and Y7-aftertaste, were evaluated by a non-trained sensory panel to obtain polynomial models for all responses. Numerical optimization resulted in the formulation: TomP (93.05%), PP (1.82%), OP (1.66%), and TPP (3.47%). Sensory analyses of the developed sauce revealed that the product was appreciated by untrained and trained panelists. Sensory profile analyses by the trained panel consensus concluded that the sauce has a good flavor profile with well-balanced sweetness and saltiness, slightly perceptible astringent notes, and no off-taste. Analyses of antioxidant activity (ABTS and FRAP), polyphenols, lycopene and beta-carotene were carried out. The sauce had concentrations of 35.37±1.85 mg/100 g (lycopene), 5.72±0.52 mg/100 g (beta-carotene), and 58.30±0.91 mg GAE/100 g (phenolic content) while the pulp had concentrations of 23.54±0.76 mg/100 g, 3.03±0.01 mg/100 g and 39.06±2.99 mg GAE/100 g, respectively. The developed tomato sauce compares favorably with the pulp in terms of lycopene, beta-carotene, and phenolic content. The remarkable increase in phenolic content, lycopene, and beta-carotene (known for their antioxidant properties) in the sauce enriched with powdered additives contributes significantly to its antioxidant potential. Therefore, the developed sauce is a good source of such health-promoting compounds and has the potential to be consumed as a functional food.
- Diversity of bioactive compounds in microalgae: key classes and functional applicationsPublication . Osathanunkul, Maslin; Thanaporn, Suebsuya; Karapetsi, Lefkothea; Nteve, Georgia Maria; Pratsinakis, Emmanouil; Stefanidou, Eleni; Lagiotis, Giorgos; Avramidou, Eleni; Zorxzobokou, Lydia; Tsintzou, Georgia; Athanasiou, Artemis; Mpelai, Sofia; Constandinidis, Constantinos; Pantiora, Panagiota; Merino, Marián; Mullor, José Luis; Dobrovic, Luka; Cerasino, Leonardo; Ogawa, Tomohisa; Tsaousi, Meropi; Rodrigues, Alexandre M. C.; Cardoso, Helena; Pires, Rita; Rodrigues Figueiredo, Daniel; Figueiredo, Daniel; Costa, Inês F.; Anjos, Catarina; Labrou, Nikolaos E.; Madesis, PanagiotisMicroalgae offer a sustainable and versatile source of bioactive compounds. Their rapid growth, efficient CO2 utilization, and adaptability make them a promising alternative to traditional production methods. Key compounds, such as proteins, polyunsaturated fatty acids (PUFAs), polyphenols, phytosterols, pigments, and mycosporine-like amino acids (MAAs), hold significant commercial value and are widely utilized in food, nutraceuticals, cosmetics, and pharmaceuticals, driving innovation across multiple industries. Their antiviral and enzyme-producing capabilities further enhance industrial and medical applications. Additionally, microalgae-based biostimulants and plant elicitor peptides (PEPs) contribute to sustainable agriculture by enhancing plant growth and resilience to environmental stressors. The GRAS status of several species facilitates market integration, but challenges in scaling and cost reduction remain. Advances in biotechnology and metabolic engineering will optimize production, driving growth in the global microalgae industry. With increasing consumer demand for natural, eco-friendly products, microalgae will play a vital role in health, food security, and environmental sustainability.
- Embedding a real-time strawberry detection model into a pesticide-spraying mobile robot for greenhouse operationPublication . Amraoui, Khalid El; Ansari, Mohamed El; Lghoul, Mouataz; Alaoui, Mustapha El; Abanay, Abdelkrim; Jabri, Bouazza; Masmoudi, Lhoussaine; LUÍS VALENTE DE OLIVEIRA, JOSÉAbstract: The real-time detection of fruits and plants is a crucial aspect of digital agriculture, enhancing farming efficiency and productivity. This study addresses the challenge of embedding a real-time strawberry detection system in a small mobile robot operating within a greenhouse environment. The embedded system is based on the YOLO architecture running in a single GPU card, with the Open Neural Network Exchange (ONNX) representation being employed to accelerate the detection process. The experiments conducted in this study demonstrate that the proposed model achieves a mean average precision (mAP) of over 97%, processing eight frames per second for 512 × 512 pixel images. These results affirm the utility of the proposed approach in detecting strawberry plants in order to optimize the spraying process and avoid inflicting any harm on the plants. The goal of this research is to highlight the potential of integrating advanced detection algorithms into small-scale robotics, providing a viable solution for enhancing precision agriculture practices.
- Enhancing therapy with nano-based delivery systems: exploring the bioactive properties and effects of apigeninPublication . Kumar, Girish; Jain, Pushpika; Virmani, Tarun; Sharma, Ashwani; Akhtar, Md Sayeed; Aldosari, Saad A; Khan, Mohd Faiyaz; Duarte, Sofia O D; Fonte, PedroApigenin, a poten t na tural flav onoid , has emerged as a key therapeutic agent due to its multifac et ed medicinal properties in combating various diseases. How ev er, apigenin’s clinical utility is greatly limited by its poor w a ter solubility, low bioav ailabilit y and stabilit y issues. To address these challenges, this review paper explores the innov a tive field of nanotechnology-based delivery sy st ems, which have shown significant promise in improving the delivery and effectiveness of apigenin. This paper also explores the synerg istic pot ential of c o-delivering apigenin with conventional therapeutic agents. Despite the advantageous properties of these nanoformulations, critical challenges such as scalable pr oduction, r egulatory appr ovals and compr ehensiv e long-term safety assessments remain key hurdles in their clinical adoption which must be addressed for commercialization of apigenin-based formulations.