FEC2-Artigos (em revistas ou actas indexadas)
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- Antibacterial, antioxidant, and antiproliferative activities of corymbia citriodora and the essential oils of eight eucalyptus speciesPublication . Miguel, Maria da Graça; Gago, Custódia; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Lagoas, Soraia; Faleiro, Maria Leonor; Megías, Cristina; Cortés-Giraldo, Isabel; Vioque, Javier; Figueiredo, Ana CristinaBackground: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+• ) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC). Antibacterial activity was evaluated using the microorganisms Streptococcus pneumoniae (strains D39 and TIGR4), and Haemophilus influenza (strain DSM 9999). The essential oils’ minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was assessed using a microdilution method. The antiproliferative activity was determined using the THP-1 cell line (human acute monocytic leukaemia) with methylthiazolyldiphenyl-tetrazolium bromide assay (MTT). Results: Corymbia citriodora and Eucalyptus viminalis EOs showed the highest ABTS and peroxyl free radical scavenging capacity. Eucalyptus globulus EO showed a high potential to treat Streptococcus pneumoniae infections. Haemophilus influenzae was the respiratory pathogen that showed the highest resistance to all EOs, including tea tree EO. After 96 h of incubation, at 25 µg/mL, Eucalyptus radiata and Eucalyptus viminalis EOs showed highest cytotoxic activity against the THP-1 cell line. Conclusions: Despite their specific bioactivities, no single EO showed simultaneously good antioxidant, antimicrobial, and antiproliferative activity.
- Mapping organizational culture, work motivation and innovative behaviour, before and during the crisis: a bibliometric analysisPublication . Rodrigues Guita Almeida, Maria Helena; Kumi, S.; Lampreia Carvalho, FatimaAbstract COVID-19 and the Russia–Ukraine war have profoundly transformed the organisational culture of many organisations, shifting from a focus on security to innovation, which poses a major challenge for managers in all aspects of service delivery, including the healthcare sector. This article addresses gaps in the literature by exploring and mapping the evolution of organisational culture, work motivation, and innovative behaviour before and during the crisis (2012–2018), and summarises the relationship between these variables in 25 selected articles. A literature review on Web of Science with bibliometric analysis and RStudio was conducted. The dynamics, associations, dimensions, and networks that emerge as a way of adapting to new contexts to foster innovation are examined. Results indicate that keywords have evolved over time, and a positive and significant relationship between organisational culture, motivation, and innovation was also identified. The findings suggest that organisations should focus on organisational culture to leverage it as a tool for motivating and fostering innovative behaviour in the workplace.
- Measuring the effect of deprivation on primary health care performance using data envelopment analysis and Malmquist IndicesPublication . Merelie, Holly Bea; Amado, Carla; Pereira dos Santos, SérgioLife expectancy is typically shorter in areas with higher deprivation, highlighting the need for policymakers and health care managers to focus on reducing health inequalities through efficient and effective care. This study aims to assess the impact of deprivation on primary health care performance using data from the National Health Service (NHS) in England. Two methods are applied: Data Envelopment Analysis (DEA) to evaluate the performance of 188 Clinical Commissioning Groups (CCGs), whose duties were recently taken on by the new Integrated Care Systems (ICSs), and the Malmquist Index (MI) to assess deprivation’s effect on performance. The DEA results reveal significant variation among CCGs in equity, efficiency, and effectiveness, indicating substantial room for improvement. The MI results show that while CCGs in more deprived areas had more resources per capita and higher efficiency, they were generally less effective than those in less deprived areas. This emphasizes the need to enhance health and social policies to address persistent health inequalities due to deprivation, a critical challenge for the new ICSs. This study illustrates how DEA and the MI can support policymakers and managers in this effort.
- Minute city concept for healthy tourism during the COVID-19 pandemic crisis. who for? The city of Lagos, PortugalPublication . Pires Rosa, Manuela; Lopes, Ana; Aghaeizadeh, Esmaeil; Gomes, André; Andraz, JorgeUrban spatial organization provided an important contribution for healthy tourism in the first COVID-19 pandemic period. The 15-Minute City concept promotes walking which is essential for the development of outdoor activities for a healthier tourism. The tourist city of Lagos (Portugal) is a pilot city of the Interreg Med SuSTowns Project which aims to promote sustainable and resilient territories. This study presents an analysis of the pedestrian accessibility through a specific geographical indicator: the percentage of short-term rentals existing in the surrounding tourist attractions. Ideal standard distances, studied internationally, were considered to assess this close proximity. Different walking speeds were considered to address human diversity and their implications on the 15-Minute City concept. The functionalities of the geographic information systems, in particular the assessment of distances over the pedestrian network were used. The results indicate that in the city of Lagos there is a trend towards an effective 15-Minute City for healthy tourists, promoting walking which could enhance tourism attraction. For tourists with reduced mobility, the use of accessible public transportation is required and needs to be integrated in the 15-Minute City concept.
- Modelling of childbearing progression among women living with HIV in Ibadan, NigeriaPublication . Akinyemi, Joshua O.; Afolabi, Rotimi; Awolude, Olutosin A.; OLAGUNJU, AHMEDBackground Childbearing is a major concern for women living with HIV especially in low-middle income countries. There are fears about access to care, risk of vertical transmission, health challenges, maternal and child morbidity/ mortality. Investigation of childbearing progression and its associated factors among these women will be useful for design of reproductive healthcare services of these women and ultimately address their multifaceted concerns. This study examined childbearing progression and its correlates another among women living with HIV in Ibadan. Method The study used a dataset from a cross-sectional study on childbearing progression among 933 respondents aged (18–49) receiving HIV care at the University College Hospital, Ibadan. Synthetic Relational Gompertz method was used to estimate fertility rate in the study population while a multistate model was developed to identify the factors associated with progression from one birth to the next. Results The average age of participants was 38 years, with majority being Yoruba tribe (80.5%). Nearly all had at least basic education (93%), and about half had 1–2 children at the time of their HIV diagnosis (47.6%). The likelihood of progressing from the first to a second birth was 77%, though no specific factors were statistically significant. However, progression to a third birth was significantly less likely (86% lower), and associated with factors such as: Having 1–2 children at HIV diagnosis (59% less likely to progress). Having more than 2 children at HIV diagnosis (94% more likely to progress), marital status (widowed women were 36% more likely to progress), partner’s education (secondary education increased the likelihood by 23%), partner’s employment status (unemployed partners increased the likelihood by 40%), desire for more children, partner’s HIV-negative status. Progression to fourth and subsequent births showed a continued decline, with the likelihood of a fourth birth being 82% lower and a fifth or sixth birth 85% lower. Women with secondary education were significantly less likely to progress to fifth births. Conclusion Overall, the corrected total fertility rate is 3.54, it’s below the national estimates and Southwest region which implies fertility is declining among women living with HIV in Ibadan. The findings revealed the relevance of socio-economic and demographic factors in childbearing progression among women living with HIV. Focused interventions should aim to provide better family planning support and integrate reproductive health counseling into HIV care programs.