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Evaluation of gold complexes to address bacterial resistance, quorum sensing, biofilm formation, and their antiviral properties against Bacteriophages

2023-10-26Journal article Open access
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dc.contributor.authorMarques, Ana
dc.contributor.authorCarabineiro, Sónia A. C.
dc.contributor.authorAureliano, M.
dc.contributor.authorFaleiro, L
dc.date.accessioned2023-12-05T10:22:10Z
dc.date.available2023-12-05T10:22:10Z
dc.date.issued2023-10-26
dc.date.updated2023-11-24T14:23:02Z
dc.description.abstractThe worldwide increase in antibiotic resistance poses a significant challenge, and researchers are diligently seeking new drugs to combat infections and prevent bacterial pathogens from developing resistance. Gold (I and III) complexes are suitable for this purpose. In this study, we tested four gold (I and III) complexes, (1) chlorotrimethylphosphine gold(I); (2) chlorotriphenylphosphine gold(I); (3) dichloro(2-pyridinecarboxylate) gold (III); and (4) 1,3-bis(2,6-diisopropylphenyl)imidazole2-ylidene gold(I) chloride, for their antibacterial, antibiofilm, antiviral, and anti-quorum sensing activities. Results reveal that 1 significantly inhibits Escherichia coli DSM 1077 and Staphylococcus aureus ATCC 6538, while 2, 3, and 4 only inhibit S. aureus ATCC 6538. The minimum inhibitory concentration (MIC) of 1 for S. aureus ATCC 6538 is 0.59 µg/mL (1.91 µM), and for methicillin-resistant S. aureus strains MRSA 12 and MRSA 15, it is 1.16 µg/mL (3.75 µM). For E. coli DSM 1077 (Gram-negative), the MIC is 4.63 µg/mL (15 µM), and for multi-resistant E. coli I731940778-1, it is 9.25 µg/mL (30 µM). Complex 1 also disrupts biofilm formation in E. coli and S. aureus after 6 h or 24 h exposure. Moreover, 1 and 2 inhibit the replication of two enterobacteria phages. Anti-quorum sensing potential still requires further clarification. These findings highlight the potential of gold complexes as effective agents to combat bacterial and viral infections.pt_PT
dc.description.sponsorshipUIDP/5006/2020pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxics 11 (11): 879 (2023)pt_PT
dc.identifier.doi10.3390/toxics11110879pt_PT
dc.identifier.eissn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.1/20183
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationNot Available
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGold complexespt_PT
dc.subjectChlorotrimethylphosphinegold (I)pt_PT
dc.subjectChlorotriphenylphosphinegold (I)pt_PT
dc.subjectDichloro (2-pyridinecarboxylate) Au (III)pt_PT
dc.subject1,3-bis(2,6-diisopropylphenyl) imidazole-2-ylidene Au(I) chloridept_PT
dc.subjectAntibacterialpt_PT
dc.subjectAntibiotic resistancept_PT
dc.subjectAntibiofilmpt_PT
dc.subjectAnti-quorum sensingpt_PT
dc.subjectAntiviralpt_PT
dc.titleEvaluation of gold complexes to address bacterial resistance, quorum sensing, biofilm formation, and their antiviral properties against Bacteriophagespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00102%2F2018%2FCP1567%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue11pt_PT
oaire.citation.startPage879pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStreamCEEC INST 2018
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAureliano
person.familyNameFaleiro
person.givenNameManuel
person.givenNameMaria Leonor
person.identifier584146
person.identifier252666
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.ciencia-id281D-5E01-F09A
person.identifier.orcid0000-0003-4858-3201
person.identifier.orcid0000-0002-3878-6948
person.identifier.ridI-3283-2012
person.identifier.scopus-author-id6603412860
person.identifier.scopus-author-id6507927018
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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