Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.

Fernández, Ignacio; Cancela, Leonor; Gavaia, Paulo J.

http://hdl.handle.net/10400.1/4350

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Authors

Fernández, Ignacio

Cancela, Leonor

Gavaia, Paulo J.

Abstract(s)

Vitamin K (VK) is a liposoluble vitamin known to be essential for bone metabolism by two different pathways: (i) by its role as a coenzyme in the gamma-carboxylation of some skeletal proteins (e.g. osteocalcin (OC) and matrix Gla protein (MGP); Price et al., 1998); and (ii) through its role in skeletal gene transcription via binding to the pregnane X receptor (PXR; Azuma et al., 2010).

URI

http://hdl.handle.net/10400.1/4350

Citation

Fernandez I., Cancela M.L., Gavaia P.J. 2012. Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.