Identification of a promoter element within the zebrafish Collagen X¿1 gene responsive to Runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2aA2

Simões, B.; Conceição, N.; S B Viegas, Carla; Pinto, Jorge; Gavaia, Paulo J.; Kelsh, R. N.; Cancela, Leonor

http://hdl.handle.net/10400.1/4764

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Identification of a Promoter Element within the Zebrafish colXα1 Gene Responsive to Runx2 Isoforms Osf2 Cbfa1 and til-1 but not to pebp2αA2.pdf		671.88 KB	Adobe PDF	Download

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Abstract(s)

Type X collagen is a short chain collagen specifically expressed by hypertrophic chondrocytes during endochondral ossification. We report here the functional analysis of the zebrafish (Danio rerio) collagen Xa1 gene (colXa1) promoter with the identification of a region responsive to two isoforms of the runt domain transcription factor runx2.

Keywords

Runx2 colXa1 Evolutionary conservation Promoter Transcriptional regulation

URI

http://hdl.handle.net/10400.1/4764

Citation

B. Simões, N. Conceição, C.S.B. Viegas, J.P. Pinto, P.J. Gavaia, R.N. Kelsh, M.L. Cancela. 2006. Identification of a promoter element within the zebrafish Collagen X1 gene responsive to Runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2αA2. Calcified Tissue International 79, 230-244