CCM2-Artigos (em revistas ou actas indexadas)
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Percorrer CCM2-Artigos (em revistas ou actas indexadas) por Objetivos de Desenvolvimento Sustentável (ODS) "04:Educação de Qualidade"
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- 2024 Annual meeting of the international network on ectopic calcification (INTEC)—abstract proceedingsPublication . Cancela, M. Leonor; Alouane, Ahmed; Bertelli, Pietro M.; Camacho, Antonio; Derudder, Robbe; Forlino, Antonella; Harris, Matthew P.; Jacinto, Marta; Lengyel, Imre; Link, Wolfgang; Murshed, Monzur; Pasch, Andreas; Kaliya-Perumal, Arun-Kumar; Quaglino, Daniela; Qin, Zihan; Sabbagh, Yves; Seminari, Elena; Villar, Marcos M.; Winkler, Christoph; Vanakker, Olivier M.The 3rd Annual Meeting of the International Network on Ectopic Calcification (INTEC) was held in Faro, Portugal on 12–13 September 2024. This hybrid meeting brought together researchers and clinicians focused on the molecular, (patho)physiological, and clinical aspects of ectopic calcification in hereditary and acquired conditions, as well as in aging. The findings presented in this year’s meeting emphasised the complexity of the field, offering new insights into both mechanistic pathways and translational hurdles. The abstracts of this year’s meeting are collected in this conference paper, with permission from the corresponding authors.
- Carreer profiles: options and insightsPublication . Krug, LilianI hold a bachelor’s degree in oceanography (2004) from the Federal University of Paraná, Brazil; a master’s degree in remote sensing (2008) from the National Institute for Space Research, Brazil; a postgraduate specialization in observational oceanography (2010) from the Nippon Foundation-Partnership for Observation of the Global Ocean (NF-POGO) Centre of Excellence in Observational Oceanography at the Bermuda Institute of Ocean Sciences, Bermuda; and a doctorate in marine and environmental sciences (2018) from the University of Algarve, Portugal. Since my undergraduate studies, I have worked on various applications of satellite remote sensing and modeled data to ocean and coastal research, including shallow water bathymetry, coral bleaching prediction, sea-air CO2 exchange, and phytoplankton phenology and variability, as well as their environmental drivers.
- Depth fluctuations of mediterranean outflow water along its northward propagation during the late pleistocenePublication . Chen, Xinyang; Wu, Jiawang; Pang, Xiaolei; Dang, Haowen; Zhong, Lifeng; Yu, Jimin; Colin, Christophe; Liu, Zhifei; Lange, Gert J. de; Kaboth‐Bahr, Stefanie; Xuan, Chuang; Ikeda, Hisashi; Herbert, Timothy D.; Huang, Huai‐Hsuan May; Zarikian, Carlos A. Alvarez; Abrantes, Fatima; Hodell, David A.Mediterranean Outflow Water (MOW) critically influences the Atlantic Meridional OverturningCirculation, yet its northward transport dynamics along the Iberian Margin remain unclear. Using terrigenousgrain‐size sortable silt and benthic foraminiferal carbon isotopes from two depth‐strategic sites (U1389:644 m vs. U1588: 1,339 m), we constrain MOW's northward depth fluctuations over the last 250 kyr. Resultsshow that MOW progressively deepened from ∼100 to 60 ka, then stabilized—synchronized with theprevalence of millennial‐scale climate variability. During interglacials, MOW directly influenced U1588,while deepened below this site during glacials. Flow speed gradients between Sites U1389 and U1588 showpronounced precession cycles. At precession maxima—Northern Hemisphere summer insolation minima—when flow intensified, MOW underwent enhanced mixing and dilution during northward transport. Thisresults from increased density contrasts between MOW and ambient waters, indicating deeper MOWpenetration. We demonstrate precessional forcing on both the strength and depth of MOW's northward propagation.
- Editors' Corner: Blubber thickness in cetaceansPublication . Canario, AdelinoWang Y, Zhang Q, Xu Q, Zhang H, Liu X, Yang G. Cetacean-specific GPR12 mutation is functionally associated with blubber thickening. Gene, volume 968, 10 October 2025, 149734. https://doi.org/10.1016 /j.gene.2025.149734. The blubber, a thick layer of fatty tissue, is a key adaptation in aquatic mammals, providing energy storage and facilitating buoyancy and locomotion (Berta, 2023). Blubber thickening has evolved independently in cetaceans (whales, dolphins, and porpoises), sirenians (manatees and dugongs), and pinnipeds (seals, sea lions, and walruses), raising questions about the genetic basis of this adaptation. Wang et al. (2025) reasoned that G protein-coupled receptor genes associated with the regulation of lipid metabolism could be involved, and homed in on GPR12, whose deficiency in mice leads to obesity and dyslipidemia (Bjursell et al., 2006)
- Feature papers in biochemPublication . Aureliano, Manuel; Ma, BuyongBiochemistry, or the chemistry of life, is an interdisciplinary science that uses strategies and methods from all exact and natural sciences. In that sense, Biochemistry is a discipline known to be challenging for students, typically due to the extent and complexity of the content [1]. However, in the last 10 years, at least fifteen Nobel Prizes in Chemistry, Physiology and Medicine have been awarded in the field and/or for applications of Biochemistry, which reflects the importance of this area of knowledge in contemporary societies [2–7]. Biochemistry connects essential metal ions such as Mg2+, Ca2+, Na+ and Fe2+, and organic compounds, such as nucleic acids, sugars, lipids and proteins, to make biological systems possible, representing a unique platform for interdisciplinary collaborations in teaching and in research [8,9]. Moreover, in addition to biomolecules (proteins, nucleic acids, sugars and lipids), small molecules are necessary for cellular homeostasis, for example, carbonate ions and phosphate ions, responsible for stabilizing physiological pH (close to 7.0) or antioxidants that prevent the effects of cellular stress, as well as due to environmental pollutants, such as metals and/or microplastics [10–12].
- Filling the gaps: new seaweed distribution records from the coast of Mozambique, Western Indian OceanPublication . Bandeira, Salomao Olinda; Américo, Maria Josefa; Santos, Rui; Amone-Mabuto, Manuela; Dias, ValeraThis paper revises and updates information on the seaweed flora of Mozambique. Out of 367 recorded species, 194 species belong to Rhodophyta, 49 to Heterokontophyta and 124 to Chlorophyta. These species represent sampling at a handful of sites, mainly at sandstone areas in southern Mozambique. Forty-seven new species were added to the list, from field expeditions carried out after 2007, covering sandstone rocky pools, crevices between rock platforms in the midlittoral transition zone to the sublittoral fringe and the sublittoral zone. This update includes a record of the kelp Ecklonia radiata in Zavora, Inhambane. Seaweed specimens were deposited at the LMU Herbarium, Eduardo Mondlane University. A value of 6.49 of the Cheney Index indicates a rather tropical seaweed flora for Mozambique. This seaweed flora update is important from a biodiversity census perspective, as well as identifying species with economic potential.
- High variability in aggression and habituation to the mirror assay in ornamental Siamese fighting fish Betta splendensPublication . Coelho da Silva, Melina; Canario, Adelino; Hubbard, Peter; Cardoso, Sara D.; Gonçalves, DavidUnderstanding consistent inter-individual variability in animal behaviour, known as personality traits, is essential for exploring the mechanisms and evolutionary consequences of behavioural diversity. Aggressive behaviour influences survival, resource acquisition, and reproduction, so clarifying individual differences can enhance our understanding of ecological dynamics and improve experimental design accuracy in behavioural studies. In this study, ornamental male Betta splendens, a model organism for aggression research, were analysed for intra- and inter-individual variability in aggressive responses to their mirror image—a standard method for assessing aggression in fish—once per week, and their consistency was evaluated over three consecutive weeks There were significant differences in aggressive behaviour across individuals, with coefficients of variation ranging from 29 to 60%. While most fish exhibited the full suite of aggressive displays, some showed no aggressive behaviour, while others only displayed threat behaviours but did not advance to the attacks. The consistency of individual threat and attack behaviours varied, but repeatability was high overall (intra-class correlation coefficients≥0.5), indicating that individual fish have different levels of aggression. There was habituation to the mirror assay, with aggression decreasing significantly by the second week, though the degree of habituation, a form of learning, varied among individuals in some behaviours. Air-breathing frequency correlated positively with aggression behaviours and can be considered an indicator to infer aggression level in this species. These results indicate that inter-individual variation in aggressive behaviour and habituation to repeated testing using the mirror assay should be considered in aggression studies using B. splendens and potentially in other species.
- Inhalable N-acetylcysteine-loaded lactose-coated PLGA nanoparticles for tuberculosis treatmentPublication . Chaudhary, Kabi Raj; Mestre Viegas, Cláudia Sofia; Pirela, Paola; Atalaia, Mariana; Ruivinho, Beatriz Lourenço; Arora, Sanchit; Singh, Arti; Brandão, Pedro; Singh, Charan; Fonte, PedroObjective Glutathione (GSH), known for having mucolytic, anti-inflammatory, and antioxidant activities, is used in clinical practice in several pathologies, including tuberculosis (TB). N-acetylcysteine (NAC) has been primarily used to treat lung conditions and paracetamol-induced liver toxicity. However, NAC exhibits potential antimycobacterial activity through several mechanisms including immunomodulation, enhancement of GSH levels, and direct antimycobacterial effect. In this work, we aim to develop an effective drug delivery system for NAC for inhalable formulations. Methods Herein, we report the development of lactose-coated NAC-loaded Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NAC-PLGA NPs) obtained by double emulsion methodology. Lactose has a double role, as a cryoprotectant agent and dispersant for inhalable formulations. The physicochemical properties of lactose-coated NAC-PLGA NPs were examined in terms of particle size, polydispersity index (PdI), zeta potential (ZP), encapsulation efficiency, and morphology. The in vitro release and lung deposition studies were assessed. Results The physicochemical characterization studies revealed the compatibility of the drug with the selected excipients. Moreover, lactose-coated NAC-PLGA NPs showed particle size of 310±3 nm, PdI of 0.15±0.01, and of -11.5±0.4 mV. The in vitro release study suggested a biphasic release profile. Likewise, in vitro lung deposition studies revealed desirable lung deposition parameters, indicating effective particle size for efficient pulmonary delivery. Additionally, in vitro studies for antimycobacterial activity exhibited superior antibacterial activity against Mycobacterium Tuberculosis (MTB) H37Rv. Conclusions These preliminary findings suggest that lactose-coated NAC-PLGA NPs can open the door to new therapeutic options against one of the most drug-refractory and drug-resistant infectious diseases, TB.
- Maternal thyroid hormone is required to develop the hindbrain vasculature in zebrafishPublication . Trindade, Marlene; Silva, Nádia; Rodrigues, Joana; Kawakami, Koichi; Campinho, Marco AntónioThyroid hormone (TH) signaling is important and necessary for proper neurodevelopment. Inadequate levels of maternally derived THs (MTH) supply affect target gene expression profiles, which are fundamental for the brain’s normal growth, maturation, and function. The monocarboxylate transporter 8 (SLC16A2, MCT8) is the main TH transporter present in the brain during embryonic development, and mutations in this transporter lead to a rare and debilitating human condition known as the Allan-Herndon-Dudley Syndrome (AHDS). This mutation affects the capacity for intracellular transport of the hormone, leading to impaired brain development that constitutes the main pathophysiological basis of AHDS. Like humans, zebrafish embryos express slc16a2 that transports exclusively T3 at zebrafish physiological temperature. Studies in zebrafish Mct8 knockdown (KD) models found impaired hindbrain vasculature development. Here, using zebrafish Mct8 KD and knockout (KO) models, we shed light on the maternal T3 (MT3)-dependent developmental mechanism behind hindbrain vasculature development. We first demonstrate that MT3-regulates hindbrain vegfaa expression. We provide evidence that hindbrain neurons are not the source of vegfaa, instead, restricted pax6a+ neuroprogenitor cells (NPCs) instruct central arteries (CtAs) ingression into the hindbrain. Therefore, MT3 acts as an integrator, providing the regulatory cues necessary for the timely ingression of the CtAs into the hindbrain.
- Open protocols, the new standard for acoustic tracking: results from interoperability and performance tests in European watersPublication . Aspillaga, Eneko; Bruneel, Stijn; Alós, Josep; Verhelst, Pieterjan; Abecasis, David; Aarestrup, Kim; Birnie-Gauvin, Kim; Afonso, Pedro; Palmer, Miquel; Reubens, JanBackground The lack of compatibility between acoustic telemetry equipment from different manufacturers has been a major obstacle to consolidating large collaborative tracking networks. Undisclosed encrypted signal cod ing protocols limit the use of acoustic telemetry to study animal movements over large spatial scales, reduce com petition between manufacturers, and stifle innovation. The European Tracking Network, in collaboration with several acoustic telemetry manufacturers, has worked to develop new transparent protocols for acoustic tracking. The results are energy-efficient transmission protocols accessible to all researchers and manufacturers. Today, the Open Protocols (OP) are already available to manufacturers and developers, and the first transmitters and receivers to implement them are already in the water. Results The main objective of this study was to confirm the compatibility between devices from different manufac turers using OP, characterise the acoustic range of each transmitter–receiver manufacturer combination, compare the detection efficiency to the standard protocols used at present (R64K and encrypted protocols), and assess its robustness against spurious detections. An international collaborative effort was made to conduct acoustic range tests in four main aquatic habitats: a river, a coastal lagoon, a coastal habitat, and the open sea. Receivers and trans mitters from different manufacturers were deployed at increasing distances from each other using the same experi mental design at each location. The decay of detection probability with distance was modelled for each transmit ter–receiver manufacturer combination by applying logistic regression using a Bayesian approach. Furthermore, to thoroughly assess performance differences in an applied research context, we conducted a direct field comparison between groups of smolts tagged with OP and R64K tags, tracking their migration to the sea. Conclusions Our results confirm full compatibility between the tested devices, with negligible differences in the measured acoustic ranges between OP manufacturers and when compared to encrypted protocols. The OP was also robust against spurious detections, and the field comparison between OP and R64K showed equal perfor mance. We hope these novel insights will encourage international research groups to promote OP-based studies to ensure compatibility and maximise the benefits of acoustic telemetry networks.