ESS2-Artigos (em revistas ou actas indexadas)
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- AB1258HPR pilot study: does a mediterranean dietbased weight loss programme improve health outcomes in overweight older women with knee osteoarthritis?Publication . Caixinha, Mónica; Mateus, Maria Palma; Pais, Sandra; Pinto, EzequielOsteoarthritis (OA) is one of the leading causes of pain and disability among older adults, particularly women. Pain and mobility disability are major consequences of knee OA which and can interfere with the functional autonomy of elderly and thus, making it difficult to perform activities of daily living. Evidence suggests that obesity is strongly linked to knee OA and that nonpharmacological therapy should be based on physical activity and weight loss in case of overweight and obesity. A positive relationship between adherence to the Mediterranean diet and health outcomes has been widely discussed in scientific literature, including its potential benefits in weight loss.
- Achados imagiológicos da COVID-19 em Tomografia Computorizada: Uma revisão narrativaPublication . Almeida, Rui; Marreiros, Rodrigo; Damásio, Afonso; Tareco, Pedro; Vicente, Simão; Alves, TomásEm dezembro de 2019, na cidade chinesa de Wuhan, foi identificado pela primeira vez em humanos uma infeção respiratória provocada pelo vírus SARS-CoV-2. A doença causada por este vírus continua a disseminar-se em todo o mundo, representando um grande problema de saúde global. Considerando que a tomografia computadorizada (TC) de tórax é um exame essencial para avaliar e determinar a extensão de lesões pulmonares que podem ocorrer, esta revisão pretende descrever os achados imagiológicos mais característicos e comuns causados pelo Covid-19.
- Adequação terapêutica da utilização de inibidores da bomba de protões: estudo exploratórioPublication . Espírito Santo, Margarida; De Sousa-Coelho, Ana Luísa; Duarte, Denise; Nascimento, TâniaO aumento acentuado do consumo de fármacos inibidores da bomba de protões (IBPs) que se tem verificado nos últimos cinco anos fez surgir a necessidade de analisar a sua utilização na prática clínica atual e avaliar as possíveis consequências associadas ao seu consumo. Pretendeu-se com este estudo analisar a adequação terapêutica da utilização de IBPs na prática clínica de uma farmácia comunitária.
- Adherence to literature search reporting guidelines in leading rheumatology journals’ systematic reviews: umbrella review protocolPublication . Pérez-Neri, Iván; Pineda, Carlos; Flores-Guerrero, Jose L.; Estêvão, M. Dulce; Vasanthan, Lenny T.; Lorente, Sonia; García-González, Renato; Devulapalli, Vighnesh; Weerasekara, Ishanka; de Aguiar, Débora Regina; Barros-Sevillano, Shamir; Le, Long Khanh-Dao; Sandoval, HugoLiterature searches are important components of systematic reviews. They are not only informative of the retrieval process, but they also set the data to be analyzed and influence additional components of systematic reviews. Despite the available guidelines, several studies have shown that the quality of reporting in systematic reviews is deficient in several medical fields. Systematic reviews may not comply completely with those guidelines despite explicitly stating they do. This protocol intends to answer to what extent systematic reviews published in rheumatology journals have complied with the PRISMA's search strategy guidelines published in 2009. The objective of the study is to analyze the compliance with the PRISMA (2009) search strategy guidelines among systematic reviews published in leading rheumatology journals. Inclusion criteria for this umbrella review protocol are systematic reviews (with or without meta-analyses) that mention having followed the PRISMA statement (2009) in their methods section, and published in journals listed in the Rheumatology category of the Journal of Citations Report 2020. Exclusion criteria are articles published before 2009; retraction letters, notes, expressions of concern; systematic reviews using PRISMA 2020. Databases to be consulted are Web of Science, PubMed and Scopus, from inception to present. Data summaries will be presented in graphs, figures, tables and network maps. A narrative synthesis will be described. This protocol complies with guidelines such as PRISMA 2020, PRISMA-A, PRISMA-P, PRISMA-S, PRESS, and JBI Manual for evidence synthesis, as long as it is suitable for umbrella review protocols. Articles in any language will be considered.
- An App about healthy habits as an educational resource during the pandemicPublication . Merino-Godoy, María de los Ángeles; Moreno-Sánchez, Emilia; Gago-Valiente, Francisco-Javier; Costa, Emília Isabel; Sáez-Padilla, JesúsEducational institutions and their agents play a fundamental role in improving people’s health literacy and quality of life. We intend here to describe and justify an educational resource embodied in an application for mobile devices developed through a subsidized project by the Ministry of Health (Government of Andalusia); the purpose of this app is to educate young people in healthy habits. The application was designed to be easily used in both smartphones and tablets with the aim of achieving good physical, psychological and social health. The project comprises several phases and the results we have so far show that, from an early age, health institutions and educational settings must work in partnership, increasing health literacy levels. This cooperative work combined with the use of this innovative approach presents an important potential for change in the lifestyles of younger generations. This type of intervention took on a special role in the pandemic context, allowing for the maintenance of the educational stimulus in a safe context.
- Analysis of dose and Acute Radio-Toxicity in breast cancer patients [ECR 2022 Book of Abstracts]Publication . Carmo, A.; Ramos, M.; Serra, F.; Abrantes, António; Rodrigues, S.; Ribeiro, L. P.; Vicente, B.; Almeida, R. P. P.Over the last 20 years, there have been significant technological and technical advances in radiotherapy for breast cancer. However acute radiationinduced skin toxicity remains a side effect impacting the quality of life in breast cancer patients. The aim of this study was to verify if there is a relationship between the dose-surface that reaches the skin and the location of acute radio toxicity.
- Analysis of opo cis-regulatory landscape uncovers Vsx2 requirement in early eye morphogenesisPublication . I, Gago-Rodrigues; Fernández-Miñán, Ana; Letelier, Joaquin; Naranjo, Silvia; Tena, Juan J.; Gómez-Skarmeta, José L.; Martinez-Morales, Juan R.The self-organized morphogenesis of the vertebrate optic cup entails coupling the activation of the retinal gene regulatory network to the constriction-driven infolding of the retinal epithelium. Yet the genetic mechanisms underlying this coordination remain largely unexplored. Through phylogenetic footprinting and transgenesis in zebrafish, here we examine the cis-regulatory landscape of opo, an endocytosis regulator essential for eye morphogenesis. Among the different conserved enhancers identified, we isolate a single retina-specific element (H6_10137) and show that its activity depends on binding sites for the retinal determinant Vsx2. Gain- and loss-of-function experiments and ChIP analyses reveal that Vsx2 regulates opo expression through direct binding to this retinal enhancer. Furthermore, we show that vsx2 knockdown impairs the primary optic cup folding. These data support a model by which vsx2, operating through the effector gene opo, acts as a central transcriptional node that coordinates neural retina patterning and optic cup invagination in zebrafish.
- Anode heel effect attenuation in lumbar spine radiography: can the use of aluminium filters improve clinical practice of radiographers?Publication . Ribeiro, Luís Pedro; Abrantes, António; Lesyuk, Oksana; Dores, Rúben; Sousa, Patrick; Rodrigues, Sónia; Almeida, Rui; Azevedo, Kevin; Soares, Joana; Aleixo, JoãoPurpose: The aim of this study was to design an aluminiumbased fi lter to reduce the anode heel eff ect in lumbar spine radiographs. Methods: Initially, lumbar spine examinations were observed in a public imaging department to determine standard exposure parameters. Then, the characterization of the anode heel eff ect was made using the Unfors Xi R/F detector and, based on the data collected, aluminium fi lters were designed with a wedge shape and thicknesses ranging from 0.1 to 4.0 mm. The assessment of the entrance skin dose (ESD) reduction was performed on the anthropomorphic phantom with and without fi lters, using the universal dosimeter UNIDOS E equipped with an ionization chamber. Finally, the image quality assessment was performed with the Pehamed Phantom Digrad A+K and image quality surveys were applied to radiographers and radiologists. Results and Discussion: Uniformity of the beam was achieved, especially with fi lter number 2, which presents a signifi cant variation of 9% between the cathodic and anodic side. This fi lter contributes to ESD reduction of 35% and 36% for AP and lateral projection, respectively. Also, according to radiographers and radiologists, it improves the image quality of lumbar spine radiography. Conclusion: The use of aluminium fi lters can be advantageous in the clinical practice of radiographers when performing lumbar spine radiographs since it allows the standardization of the anode heel eff ect, reduces the radiation dose to the patient and does not compromise image quality.
- Anterior femoral cut in total knee arthroplasty: a classification proposalPublication . Medeiros, Filipe; Duarte, António; Correia, Bruno; Carvalho, Maria; Vide, João; Fontes, Ana Paula; Sousa, João PauloBackground: The cut of the anterior femur (CAF) sets the rotation of the femoral component, which could affect patellar tracking, and influence the clinical results on total knee arthroplasty (TKA). The aim of this study was to suggest a classification for anterior femoral cut in TKA. Methods: Images of anterior femoral cuts were aggregated in different shapes and defined a classification. Onehundred femoral image’s cuts were analysed by 5 orthopaedic surgeons, which classified them twice. To analyse inter and intra-observer agreement, the Fleiss Kappa test was used. Results: The study proposes the following CAF classification, type 1 (one peak) and type 2 (two peaks); subtypes 1 (a) a central base peak, 1 (b) a lateral base peak, 2 (a) two peaks where the smallest is in the lower half, and 2 (b) two peaks where the smallest is in the upper half. In our study, type 2 (a) was the most common type (54.5%), followed by type 1 (b). The analysis showed good intra- and inter-observer agreements (mean K of 0.774 and 0.627, respectively). The intra and inter-observer concordance was statistically significant in all the analyses. Conclusions: The CAF classification system for TKA is considered a reproducible classification. To our knowledge, there is no study describing a shape’s classification of this cut. A slight rotation of the femoral cutting guide could change the axial rotation and positioning of the femoral component. An undesirable cut could lead to different patellofemoral offset and could consequently cause anterior pain and instability.
- Anxiety and depression in the initial stage of the COVID-19 outbreak in a Portuguese sample: exploratory studyPublication . José, Helena; Oliveira, Cláudia; Costa, Emília; Matos, Filomena; Pacheco, Eusébio; Nave, Filipe; Valentim, Olga; Sousa, LuísIn previous studies, it was found that the confinement to which the population was subjected during the quarantine of the COVID-19 pandemic increased the risk of anxiety and depression. Objective: to analyze the levels of anxiety and depression symptoms in Portugal residents during the quarantine of the COVID-19 pandemic. Methods: This is a descriptive, transversal, and exploratory study of non-probabilistic sampling. Data collection was carried out between 6th and 31st of May 2020. Sociodemographic and health questionnaires PHQ-9 and GAD-7 were used. Results: The sample consisted of 920 individuals. The prevalence for depressive symptoms (PHQ-9 ≥ 5) was 68.2% and (PHQ-9 ≥ 10) was 34.8%, and for anxiety symptoms (GAD-7 ≥ 5) was 60.4% and (GAD-7 ≥ 10) was 20%. Depressive symptoms were moderately severe for 8.9% of the individuals, and 4.8% presented severe depression. Regarding the generalized anxiety disorder, we found that 11.6% of individuals present moderate symptoms, and 8.4% severe anxiety symptoms. Conclusions: The prevalence of depressive and anxiety symptoms were substantially higher than those previously found for the Portuguese population and when compared with other countries during the pandemic. Younger individuals, female, with chronic illness and medicated, were more vulnerable to depressive and anxious symptoms. In contrast, participants who maintained frequent levels of physical activity during confinement had their mental health protected.