Screening of breast lesions: a comparative study between mammography, B-mode ultrasonography, sonoelastography and histological results

Pardal, Raquel Constantino; Abrantes, António; Ribeiro, Luís Pedro; Almeida, Rui; Azevedo, Kevin; Figueiredo, Teresa Leonor; Rodrigues, Sónia

http://hdl.handle.net/10400.1/17927

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Authors

Pardal, Raquel Constantino

Figueiredo, Teresa Leonor

Rodrigues, Sónia

Abstract(s)

To compare the capacity of mammography, sonoelastography, B-mode ultrasonography and histological analysis to differentiate benign from malignant breast lesions. Materials and Methods: A total of 12 histopathologically confirmed breast lesions were documented. The lesions were assessed by means of mammography, B-mode ultrasonography and sonoelastography, and histopathological analysis was utilized as a gold standard. Sensitivity and specificity were calculated. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic performance of the mentioned techniques. Results: Sensitivity and specificity in the differentiation between benign and malignant lesions were respectively 100% and 50% for mammography, 100% and 71% for B-mode ultrasonography, and 67% and 83% for sonoelastography. The area under the ROC curve was calculated for the three imaging modalities and corresponded to 0.792 for mammography, 0.847 for B-mode ultrasonography, and 0.806 for sonoelastography. Conclusion: Sonoelastography demonstrated higher specificity and lower sensitivity as compared with mammography and B-mode ultrasonography. On the other hand, B-mode ultrasonography had the largest area under the ROC curve. Sonoelastography has demonstrated to be a promising technique to detect and evaluate breast lesions, and could potentially reduce the number of unnecessary biopsies.