Isolation and characterization of piscine osteonectin and downregulation of Its expression by PTH-related protein

Redruello, Begoña; Estêvão, M. Dulce; Rotllant, J.; Guerreiro, P. M.; Anjos, Liliana; Canario, Adelino V. M.; Power, Deborah

http://hdl.handle.net/10400.1/3908

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Authors

Canario, Adelino V. M.

Power, Deborah

Abstract(s)

The skeleton is the main source of osteonectin mRNA in adults of the seawater teleost sea bream Sparus auratus. It is expressed by cells forming the basement membrane of calcifying tissue indicating that, as in mammals, it may play a role in osteoblast differentiation. PTHrP induced downregulation of osteonectin mRNA in vitro in scales, a mineralizing tissue with bone-like metabolism. This indicates a means to redirect calcium to activities such as vitellogenesis when this ion is in high demand.

Keywords

Osteonectin Extracellular matrix Fish skeleton PTH-related peptide Scales

URI

http://hdl.handle.net/10400.1/3908

Citation

Begoña Redruello; Estêvão, Maria Dulce da Mota Antunes de Oliveira; Josep Rotlland; Pedro M. Guerreiro; Liliana I. Anjos; Adelino V. M. Canário; Deborah M. Power. Isolation and Characterization of Piscine Osteonectin and, JOURNAL OF BONE AND MINERAL RESEARCH, 20, 4, 682-692, 2005